John E. Hannappel

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1. The normal ureteral peristalsis of the guinea-pig was determined by long-term recordings of electrical activity in the unanaesthetized animal. The frequency distribution of peristaltic period durations is multimodal. The normal basic frequency is 6/min, calculated from the first mode. Great variations in the manifest frequency of peristalsis are(More)
Ureteral peristalsis was measured in unanaesthetized dogs and in isolated preparations of dogs and rats. The normal pacemaker is localized — as in the guinea-pig — in the proximal parts of the renal pelvis. The frequency distribution of peristaltic intervals is multimodal, with harmonic relations between the mode values. In the unanaesthetized dog, the(More)
PURPOSE The loss of a functioning bladder is nowadays mostly managed by replacement with gastrointestinal segments. Management of these urinary diversions is difficult and the long-term effects are unknown. We developed a silicone rubber prosthesis for alloplastic replacement of the urinary bladder and tested it in an animal experiment. MATERIAL AND(More)
The mechanical activity of isolated strips from different areas of the pyeloureteral system was investigated in 10 pigs: calyx, renal pelvis, pyeloureteral junction and ureter. Additionally, electrical activity was measured in some pyeloureteral preparations using the sucrose-gap technique. Regular spontaneous activity with an average frequency of 9.5/min(More)
Clinical efficacy and adverse effects of oxybutynin and propantheline in the treatment of symptoms related to detrusor hyperactivity were studied in a randomized, controlled, double-blind multicenter trial. Of 169 patients entered into the study 154 were evaluable for statistical analysis. Mean grade of improvement (visual analogue scale) was significantly(More)
In isolated muscle strips of porcine renal pelvis and ureter, the calcium antagonist nifedipine (3·10−7 moles/l) completely suppressed spontaneous phasic mechanical activity and the phasic components of an adrenaline-induced activation (P-component). In the presence of nifedipine, adrenaline induced in pelvis preparations (but not in the ureter) a tonic(More)
The effects of adrenaline and noradrenaline and of α- and β-receptor blocking agents on electrical and mechanical activity of the pyeloureteral system were investigated in unanaesthetized dogs and guinea-pigs and in isolated preparations of dogs, rats and guinea-pigs. The catecholamines produce, via α-receptors, positive autochthonotropic and chronotropic(More)
To determine the precise localization of the pacemaker in the renal pelvis of the unicalyceal rabbit kidney, the spontaneous activity of muscle strip preparations was investigated in vitro. (1) The highest frequency of spontaneous contractions was found in the most intrarenal part of the renal pelvis. (2) The frequency diminished from the most intrarenal(More)
The alpha-adrenergic innervation of the functional urethra is a well-known fact, while beta-adrenergic influence is rather unknown until now. We studied the influence of beta-stimulating and beta-blocking agents on the human urethra by the urethral pressure profile (UPP). A decrease of the UPP under orciprenaline sulfate and an increase under propranolol(More)