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Preferential usage of JH-proximal VH genes has been demonstrated in immature murine B cell repertoires. To determine whether this phenomenon is also evident in human repertoires, we studied utilization of VH6, the most JH-proximal human VH gene. Examination of VH gene usage in a panel of precursor B cell acute lymphoblastic leukemia samples indicated that(More)
The Blue Genet/L chip is a technological tour de force that embodies the system-on-a-chip concept in its entirety. This paper outlines the salient features of this 130-nm complementary metal oxide semiconductor (CMOS) technology, including the IBM unique embedded dynamic random access memory (DRAM) technology. Crucial to the execution of Blue Gene/L is the(More)
We have previously demonstrated a dramatic preference for utilization of the most JH-proximal VH gene segments in the newborn liver versus adult spleen. We now examine in detail the relative expression of different VH gene families throughout ontogeny and in immunodeficient mice to gain insight into factors that cause the shift in VH usage. We find that the(More)
This paper presents an overview of the macro design, architecture, and built-in self-test (BIST) implementation as part of the IBM third-generation embedded dynamic random-access memory (DRAM) for the IBM Blue Logic ® 0.11-␮m application-specific integrated circuit (ASIC) design system (CU-11). Issues associated with embedding DRAM in an ASIC design are(More)
The human VH5 family consists of two functional genes and one pseudogene. We have found a novel 1.2-kb VH5 gene transcript in normal fetal liver and cord blood and in transformed B lineage cells. VH5-positive cDNA clones were isolated from precursor B acute lymphoblastic leukemia, B chronic lymphoblastic leukemia, Epstein-Barr Virus-transformed B cell(More)
An 18Mb DRAM has been designed in a 3.34, 0.5-pm CMOS process. The array consists of four independent, self-contained 4.5Mb quadrants. The chip output configuration defaults to 1 Mb x 18 for optimization of wafer screen tests, while 3. 3 4 or 5. 0 4 operation is selected by choosing one of two M2 configurations. Selection of 2Mb x 9 or 1 Mb x 18 operation(More)
A spherical and chromatic aberration corrector for electron microscopes is proposed, consisting of a thin foil sandwiched between two apertures. The electrons are retarded at the foil to almost zero energy, so that they can travel ballistically through the foil. It is shown that such a low-voltage corrector has a negative spherical aberration for not too(More)