John E Agnew

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75Se-selenomethionine scanning in the diagnosis of tumours of the pancreas and adjacent viscera: The use of the test and its impact on survival SUMMARY The results ofpancreatic scanning with 75Se-selenomethionine in 393 carefully documented patients over a two-year period are presented. On follow up 50 patients had operatively proven malignant tumours in(More)
STUDY OBJECTIVE To assess the effects of tiotropium on lung mucociliary clearance in COPD. DESIGN Randomized, double-blind, placebo-controlled, parallel-group study. SETTING Outpatients of an urban-area university teaching hospital. PATIENTS Thirty-four patients with COPD aged 40 to 75 years classified equally into two groups. INTERVENTION Single(More)
Tracheobronchial clearance was measured by a radioaerosol technique in 12 patients with bronchiectasis, seven patients with chronic obstructive lung disease expectorating mucoid sputum daily (group X), eight patients with chronic obstructive lung disease but negligible sputum expectoration (group Y), and 10 healthy subjects. The patients with bronchiectasis(More)
BACKGROUND Bradykinin, a nonapeptide that contributes as a mediator to the pathogenesis of asthma, may affect lung mucociliary clearance, as it has been shown to be a potent secretagogue in canine airways and in human nasal mucosa in vivo. To evaluate this possibility the effect of inhaled bradykinin on mucociliary clearance has been studied in 10 healthy(More)
Data on the effect on mucociliary clearance of oral high frequency oscillation is conflicting. By means of a technique to superimpose high frequency oscillation on tidal breathing, changes in mucociliary clearance during high frequency oscillation were studied in seven normal non-smokers by monitoring the clearance of inhaled radiolabelled aerosol from the(More)
We studied eight young smokers and ten nonsmokers, to determine whether respiratory epithelial permeability to radiolabelled diethylenetriamine penta-acetate (99mTcDTPA) was related to small airway function or bronchial reactivity. Permeability was measured in inner (containing central airways) and outer lung zones by gamma camera. Lung-to-blood half-time(More)
Smoking induced changes in the secretory cells of bronchiolar epithelium by facilitating secretion of cross linked glycoprotein mucus may influence the efficiency of mucus-cilia coupling. The functional impact on mucociliary transport in small (peripheral) airways has been studied by comparing data on aerosol deposition and clearance from symptomless(More)
Nasal and tracheobronchial mucociliary clearance have been compared in 10 healthy subjects. Nasal clearance was measured by monitoring the rate of removal of 2 jm diameter Teflon particles, labelled with 99mTc, which had been placed in the anterior part of the nose. Tracheo-bronchial clearance was measured with an objective radioaerosol technique, 5 um(More)
  • J E Agnew
  • 1996
We have often, and over a long time, thought of the "small airways" as a mystery zone or a quiet zone [1]. Relative to central bronchial generations, the total cross-sectional area of each bronchiolar generation is large. Airflow resistance should in consequence be low. Considerable changes due to disease could, thus, occur with little chance of being(More)