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Nine subjects (5 women) aged between 17-66 years, with hydrocephalus were studied. An external ventricular drain was introduced for diagnostic purposes. Cerebro-spinal fluid (CSF) and plasma samples were obtained at suitable intervals after 1 h infusion of 400 mg pefloxacin. In plasma, pefloxacin Cmax was 8.54 +/- 1.53 (mean +/- S.E.M.) mg/l, at the end of(More)
A fully automated high-performance liquid chromatographic method is described for the determination of spiramycin 1 in plasma. First, 1 ml of plasma is diluted with 1.5 ml of 4% acetonitrile containing spiramycin 2 as internal standard, and 1 ml is then injected via an automatic sampling unit. A pneumatic valve, which is remote-controlled by the(More)
The Navigation Office at ESOC has been closely involved in all aspects of the Precise Orbit Determination (POD) of Envisat throughout the mission lifetime. These activities started shortly after launch through membership of the Orbit Validation Team (OVT). During this time ESOC was involved in both calibration and validation of the DORIS doppler data, the(More)
The design and operational parameters of a high-power pulser suitable for a photo-impulse ionized laser are presented. The relatively compact device utilizes a ceramic thyratron in a triggered resonant charging circuit. Efficient operation at repetition rates up to 40 kHz, with pulsed powers in excess of 2 MW and average powers of several kilowatts has been(More)
The structure of adenosine 3',5'-cyclic phosphate has been determined by single-crystal x-ray diffraction. The two molecules in the asymmetric unit show different conformation about the glycosidic bond, while other structural details are essentially the same. The furanose rings are puckered with the C(4') atom out of the best four-atom plane. The bond(More)
The construction technique and resulting electrical performance of high-voltage impulse transformers for ''pulser-sustained'' laser applications is presented. The compact structures exhibit excellent rise-time and power-handling capacity over a wide range of operating conditions. The distributed core geometry permits impulse power operation at several(More)
The design and operational features of a fluid-ballasted electrode structure for a high powered EDL CO(2) laser are described. This new device incorporates a crossed-tube geometry and as such is much simpler and inexpensive to fabricate than previous multielement or pin electrodes. Hot boundary layer formation at the electrode surfaces is minimized by a(More)