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Mutations in the Pseudomonas aeruginosa Needle Protein Gene pscF Confer Resistance to Phenoxyacetamide Inhibitors of the Type III Secretion System
The results implicate the PscF needle protein as an apparent new molecular target for T3 SS inhibitor discovery and suggest that three other chemically distinct T3SS inhibitors interact with one or more different targets or a different region of Pscf.
Identification of a Small-Molecule Entry Inhibitor for Filoviruses
It is hypothesized that compound 7 binds to this hydrophobic pocket at or near the GP1 and GP2 interface and as a consequence inhibits EBOV infection of cells, but the details of the mechanism remain to be determined.
Discovery and Characterization of Inhibitors of Pseudomonas aeruginosa Type III Secretion
Five inhibitors in three chemical classes were demonstrated to inhibit type III secretion selectively with minimal cytotoxicity and with no effects on bacterial growth or on the type II-mediated secretion of elastase.
Novel Small Molecule Entry Inhibitors of Ebola Virus.
2 novel EBOV inhibitors, MBX2254 and MBX2270, are identified that can serve as starting points for the development of an anti-EBOV therapeutic agent and highlight the importance of NPC1-GP interaction in E BOV entry and the attractiveness of NPC 1 as an antifiloviral therapeutic target.
Comparative In Vitro Activity Profiles of Novel Bis-Indole Antibacterials against Gram-Positive and Gram-Negative Clinical Isolates
The bis-indole compounds show promise for the treatment of multidrug-resistant clinical pathogens and compared favorably to all comparator antibiotics.
New Small Molecule Entry Inhibitors Targeting Hemagglutinin-Mediated Influenza A Virus Fusion
Two novel inhibitors, MBX2329 and MBX2546, with aminoalkyl phenol ether and sulfonamide scaffolds that specifically inhibitHA-mediated viral entry represent new starting points for chemical optimization and have the potential to provide valuable future therapeutic options and research tools to study the HA-mediated entry process.
Human Cytomegalovirus UL97 Kinase Is Involved in the Mechanism of Action of Methylenecyclopropane Analogs with 6-Ether and -Thioether Substitutions
HCMV UL97 kinase is involved in the antiviral action of these MCPNs, but the in vitro selection of UL97-defective viruses suggests that their activity against more typical ganciclovir-resistant growth-competent UL97 mutants may be relatively preserved.
Ecology and Status of Piscivores in Guri, an Oligotrophic Tropical Reservoir
Abstract Guri Reservoir in Venezuela supports sport fisheries for two cichlid species (pavon venado or speckled pavon Cichla temensis and pavon mariposa C. orinocensis) and payara Hydrolycus
Synthesis and antiviral activity of novel erythrofuranosyl imidazo[1,2-a]pyridine C-nucleosides constructed via palladium coupling of iodoimidazo[1,2-a]pyridines and dihydrofuran.
When screened for anti-HCMV and HSV-1 activity, the alpha-d anomer of 2,6,7-trichloro-3-(erythrofuranosyl)imidazo[1,2-a]pyridine proved to be the most active member of the series, while the beta-anomers all proved to been inactive.