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Abstract 719 Background: Fludarabine (FLU), cyclophosphamide and rituximab or other FLU based regimens have shown improvement in response rates, progression-free survival, and in some studies overall… (More)
Current bevacizumab-based regimens have failed to improve survival in patients with recurrent glioblastoma. To improve treatment efficacy, we evaluated bevacizumab + BKM120, an oral pan-class I PI3K… (More)
Abstract Nausea and vomiting are common adverse effects of chemotherapy and are among the effects most feared by patients. Vomiting associated with chemotherapy is triggered centrally by a number of… (More)
Abstract Background Therapies targeting estrogen receptor signaling are standard for patients with hormone receptor positive (HR+) metastatic breast cancer (MBC). Dysregulation of the PI3K/AKT/mTOR… (More)