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BACKGROUND Brain glutathione levels are decreased in schizophrenia, a disorder that often is chronic and refractory to treatment. N-acetyl cysteine (NAC) increases brain glutathione in rodents. This study was conducted to evaluate the safety and effectiveness of oral NAC (1 g orally twice daily [b.i.d.]) as an add-on to maintenance medication for the(More)
Models are central to scientific thinking and essential to many kinds of practical problem-solving. Imbued with different meanings in different contexts, the word model implies structure and relationships among variables and also conveys tentativeness and incompleteness. Building models for science differs from building models for problem solving because(More)
OBJECTIVE To examine the rate and characteristics of seclusion among a group of patients admitted to an adult acute psychiatric unit as a precursor to planning an audit cycle and quality improvement project. METHODS A retrospective chart review of all inpatient admissions to an adult acute unit over a 12 month period was undertaken with the use of a(More)
INTRO Binge eating disorder (BED) affects 3.5% of the population and is characterized by binge eating for at least 2 days a week for 6 months. Treatment options include cognitive behavioral therapy, interpersonal psychotherapy, and pharmacotherapy which are associated with varied success. Little is known about the biology of BED. Since there is evidence(More)
OBJECTIVE The aim of this study was to demonstrate the clinical use of a patient-based voucher system for brief hospitalisation. CLINICAL PICTURE A 31-year-old male, chronically disabled, with schizophrenia, polysubstance, and borderline personality disorders presented concerns for the treating team. TREATMENT Management was community based except for a(More)
OBJECTIVE We report a patient who developed discontinuation symptoms following nefazodone cessation. CLINICAL PICTURE The patient experienced nausea, vomiting, diarrhoea, ataxia, insomnia, marked agitation, headache and flu-like symptoms. TREATMENT She was reluctant to recommence nefazodone and was symptomatically treated with oxazepam. OUTCOME The(More)