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BACKGROUND & AIMS Sustained activation of the cytosolic calcium concentration induces injury to pancreatic acinar cells and necrosis. The calcium release-activated calcium modulator ORAI1 is the most abundant Ca(2+) entry channel in pancreatic acinar cells; it sustains calcium overload in mice exposed to toxins that induce pancreatitis. We investigated the(More)
ACKNOWLEDGEMENT We express our profound gratitude to Elaine Daily-Birnbaum whose critical questions, editorial skills, and lingquistic abilities were significant in making this document what it has become. We also are deeply in debt to Kathie Campbell who unselfishly devoted her time and professional skills to convert our manuscript into this book. Without(More)
Purpose: GVHD after allogeneic hematopoietic stem cell transplantation (alloSCT) has been associated with low numbers of circulating CD4 þ CD25 þ FoxP3 þ regulatory T cells (Tregs). Because Tregs express high levels of the interleukin (IL)-2 receptor, they may selectively expand in vivo in response to doses of IL-2 insufficient to stimulate T effector(More)
We present a comprehensive review of perceptions and methods around the Ecological Footprint (EF), based on a survey of more than 50 international EF stakeholders and a review of more than 150 original papers on EF methods and applications over the last decade. The key points identified in the survey are that the EF (a) is seen as a strong communication(More)
The Water Footprint, as an indicator of water consumption has become increasingly popular for analyzing environmental issues associated with the use of water resources in the global supply chain of consumer goods. This is particularly relevant for countries like the UK, which increasingly rely on products produced elsewhere in the world and thus impose(More)
Please let this letter serve as a suggestion of the need for correction of an error in the official case caption in this matter. That caption names the Director of the Texas Department of Public Safety as Steve McGraw (with a G). The Director's name is properly spelled Steve McCraw (with two Cs). See Tex. Dep't of Pub. Safety, suggest that the Court correct(More)
The scenarios generated by energy systems models provide a picture of the range of possible pathways to a low-carbon future. However, in order to be truly useful, these scenarios should not only be possible but also plausible. In this paper, we have used lessons from historical energy transitions to create a set of diagnostic tests to assess the feasibility(More)
Rapid economic growth in Northwest China has been accompanied by a dramatic increase in carbon emissions. Based on the two-level Logarithmic Mean Divisia Index (LMDI) method, this study decomposes changes in energy-related carbon emissions in Northwest China during 1995–2012 from the regional and provincial perspectives. Further, by constructing an expanded(More)