John Constant

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BACKGROUND Despite the availability of potent antibiotics and intensive care, mortality rates from septic shock are 40-70%. We assessed the safety and efficacy of murine monoclonal antibody to human tumour necrosis factor alpha (TNF alpha MAb) in the treatment of septic shock. METHODS In a randomised, multicentre, double-blind, placebo-controlled clinical(More)
invited speaker: irene Tracey nuffield Professor anaesthetic science & director, oxford centre for fMri of Brain, nuffield department of clinical neurosciences, (head, nuffield division anaesthetics), oxford university, england, uK The ability to experience pain is old and shared across species. It confers an evolutionary advantage and provides a warning of(More)
The neurobehavioral and pathologic features of Parkinson disease dementia (PDD) are virtually identical to those of dementia with Lewy bodies (DLB), suggesting that they represent different phenotypes of the same underlying disease. Both are characterized clinically by a "frontal-subcortical" dementia, fluctuating confusion, and, often, psychotic symptoms.(More)
A simplified method of diagnosing anterior divisional blocks (hemiblocks) at a glance is made possible by using a knowledge of the lead line directions on a hexaxial system. The term 'divisional block' is preferred to 'hemiblock' because a block of one of the three divisions of the left bundle cannot be a hemiblock. The diagnosis of an anterior divisional(More)