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For the past two decades notions of " cumulative tradition " and " reference disciplines " have been a significant part of the introspective debates on the IS field. We provide an 1 Detmar Straub was the accepting senior editor. This paper was submitted on June 5, 2004, and went through three revisions. 2 We are indebted to Detmar Straub, and three(More)
Data on the tissue distribution of morphine and codeine in rat are presented. The concentration of these two opiate alkaloids seems to be distributed uniformly in the cortex, midbrain, pons/medulla and cerebellum. The spinal cord and the adrenal gland have high levels of morphine and codeine and the adrenal has more codeine than morphine. The major fraction(More)
Using an immunohistochemical approach we have characterized the in vivo developmental distribution of myelin oligodendrocyte glycoprotein within the rat CNS. Myelin oligodendrocyte glycoprotein expression emerged in a non-uniform manner during the first 3 postnatal weeks. Although it was absent throughout the CNS of the newborn rat at postnatal day 0(P0),(More)
  • George Goehring, Thomas Reichherzer, Eman El-Sheikh, Dallas Snider, Norman Wilde, Sikha Bagui +2 others
  • 2013
—Rule-based methods have traditionally been applied to develop knowledge-based systems that replicate expert performance on a deep but narrow problem domain. Knowledge engineers capture expert knowledge and encode it as a set of rules for automating the expert's reasoning process to solve problems in a variety of domains. We describe the development of a(More)
BACKGROUND As part of conducting a randomized control trial (RCT) to treat chronically high utilizing patients with medically unexplained symptoms (MUS), we developed the chart rating method reported here to identify and classify MUS subjects. METHOD Intended at this point only as a research tool, the method is comprehensive, uses explicit guidelines, and(More)
Tumour stroma gene expression in biopsy specimens may obscure the expression of tumour parenchyma, hampering the predictive power of microarrays. We aimed to assess the utility of fluorescence-activated cell sorting (FACS) for generating cell populations for gene expression analysis and to compare the gene expression of FACS-purified tumour parenchyma to(More)
Karpicke and Blunt (Reports, 11 February 2011, p. 772) reported that retrieval practice produces greater gains in learning than elaborative studying with concept mapping and concluded that this strategy is a powerful way to promote meaningful learning of complex concepts commonly found in science education. We question their findings on methodological and(More)
OBJECTIVES The relevance of spatial composition in the microbial changes associated with UC is unclear. We coupled luminal brush samples, mucosal biopsies and laser capture microdissection with deep sequencing of the gut microbiota to develop an integrated spatial assessment of the microbial community in controls and UC. DESIGN A total of 98 samples were(More)
In today's information society, computer-supported collaborative learning (CSCL) has become increasingly important. However, there are still problems regarding CSCL, especially interaction problems within groups. This study is an investigation of whether a specific kind of awareness tool, namely a tool for making the collaborators aware of relevant domain(More)
Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some cases, worsened disease outcome. Here we examine colon cancer patients and show not only that PKC Beta II is a tumour suppressor, but(More)