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For the past two decades notions of " cumulative tradition " and " reference disciplines " have been a significant part of the introspective debates on the IS field. We provide an 1 Detmar Straub was the accepting senior editor. This paper was submitted on June 5, 2004, and went through three revisions. 2 We are indebted to Detmar Straub, and three(More)
OBJECTIVES The relevance of spatial composition in the microbial changes associated with UC is unclear. We coupled luminal brush samples, mucosal biopsies and laser capture microdissection with deep sequencing of the gut microbiota to develop an integrated spatial assessment of the microbial community in controls and UC. DESIGN A total of 98 samples were(More)
Using an immunohistochemical approach we have characterized the in vivo developmental distribution of myelin oligodendrocyte glycoprotein within the rat CNS. Myelin oligodendrocyte glycoprotein expression emerged in a non-uniform manner during the first 3 postnatal weeks. Although it was absent throughout the CNS of the newborn rat at postnatal day 0(P0),(More)
Tumour stroma gene expression in biopsy specimens may obscure the expression of tumour parenchyma, hampering the predictive power of microarrays. We aimed to assess the utility of fluorescence-activated cell sorting (FACS) for generating cell populations for gene expression analysis and to compare the gene expression of FACS-purified tumour parenchyma to(More)
In today's information society, computer-supported collaborative learning (CSCL) has become increasingly important. However, there are still problems regarding CSCL, especially interaction problems within groups. This study is an investigation of whether a specific kind of awareness tool, namely a tool for making the collaborators aware of relevant domain(More)
OBJECTIVE The aims of this study were to develop techniques for spatial microbial assessment in humans and to establish colonic luminal and mucosal spatial ecology, encompassing longitudinal and cross-sectional axes. DESIGN A microbiological protected specimen brush was used in conjunction with a biopsy forceps to sample the colon in nine healthy(More)
INTRODUCTION The national junior doctor recruitment crisis prompts an appraisal of medical student attitudes to different career pathways. The purpose of this study was to perform a national review of surgical career intentions of Irish final year medical students. METHODS Ethical and institutional approval was obtained at each study location. A(More)
BACKGROUND As part of conducting a randomized control trial (RCT) to treat chronically high utilizing patients with medically unexplained symptoms (MUS), we developed the chart rating method reported here to identify and classify MUS subjects. METHOD Intended at this point only as a research tool, the method is comprehensive, uses explicit guidelines, and(More)
The colonic mucus gel layer (MGL) is a critical component of the innate immune system acting as a physical barrier to microbes, luminal insults, and toxins. Mucins are the major component of the MGL. Selected microbes have the potential to interact with, bind to, and metabolize mucins. The tolerance of the host to the presence of these microbes is critical(More)