John Christiansen

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BACKGROUND In patients with faecal incontinence in whom conservative treatment fails, options are limited for those with a functionally deficient but morphologically intact sphincter. We investigated the effect of sacral nerve stimulation on continence and quality of life. METHODS In this multicentre prospective trial, 37 patients underwent a test(More)
BACKGROUND & AIMS Dynamic muscle plasty has been advocated as therapy for refractory fecal incontinence and for anorectal reconstruction to avoid colostomy after abdominoperineal resection. This study evaluates the results of a multicenter experience with dynamic muscle plasty in the treatment of fecal incontinence and total anal reconstruction. METHODS(More)
PURPOSE Dynamic graciloplasty has been used for intractable fecal incontinence, and good results have been reported. The aim of this study was to assess prospectively the safety and efficacy of dynamic graciloplasty for intractable fecal incontinence in a prospective, multicenter trial. METHODS A total of 123 adults were treated with dynamic graciloplasty(More)
We studied the effect of intravenous infusion of synthetic truncated GLP-1 (proglucagon 78–107-amide) on fasting and postprandial gastric acid secretion, gastric emptying, and pancreatic secretion of trypsin and lipase in eight normal volunteers using marker dilution and aspiration technique. The infusion resulted in a plasma concentration of 110±14(More)
An attempt is made to establish the most appropriate examination procedure for staging rectal carcinoma by computed tomography (CT). Twentytwo patients with rectal carcinoma had CT performed preoperatively. The following three CT sequences were performed in all patients: a precontrast scan with 10-mm slices; a rapid sequence scan with 5-mm slices during(More)
INTRODUCTION Sacral nerve stimulation for the treatment of faecal incontinence has gained increasing use in Europe over the last two years. Experience with the first patients treated in Denmark is described here. MATERIAL AND METHODS Fourteen patients with severe faecal incontinence were given sacral nerve stimulation. The first treatment was temporary,(More)
PURPOSE Anal sphincter replacement offers a new treatment option for patients with severe refractory fecal incontinence or for those who require abdominoperineal resection for localized malignancy. The purpose of this study was to review the current status of anal sphincter replacement, formulate a consensus statement regarding its current use, and outline(More)
PURPOSE Patients with end-stage fecal incontinence in whom all standard medical and surgical treatment has failed or is not expected to be effective can be treated by dynamic graciloplasty. The aim of this study was to review the long-term efficacy data. METHODS Success was defined as a greater than 50 percent decrease in the frequency of incontinent(More)
PURPOSE Dynamic graciloplasty can improve continence in patients with severe refractory fecal incontinence, but associated morbidity is high. The purpose of this study was to identify complications associated with dynamic graciloplasty and to characterize their treatment and impact on patient outcome. METHODS In 121 patients enrolled in a prospective(More)
Only two of the epidemics of the English sweating sickness have been the subject of modern demographic studies. Robert Gottfried analysed the mortality of the 1485 epidemic by studying probated wills, and John Wylie and Ian Linn, and more recently Alan Dyer, analysed the 1551 epidemic on the basis of parish burial registers. The epidemic of the sweat in(More)