John Ching-Jen Hsiao

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The dystrophin-deficient, X-linked dystrophic mouse (mdx) was used to evaluate the efficacy of prednisolone treatment. A test protocol was used to take advantage of the quantifiable weakness and disability as well as molecular genetic defect shared with the X-linked Duchenne muscular dystrophy (DMD). Whole-body weakness and fatigue were determined by(More)
In monkeys, unilateral intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a useful model of hemiparkinsonism. To evaluate MPTP-induced neurochemical changes in vivo, brain microdialysis was employed to measure extracellular levels of dopamine and its metabolites in the neostriatum of normal and hemiparkinsonian rhesus(More)
In vivo biochemical microdialysis in primate brain would greatly expand our understanding of functional neuronal systems. This work describes our efforts to establish a microdialysis system in primate brain. Seven anesthetized rhesus monkeys underwent magnetic resonance imaging (MRI) with the head fixed in a compatible stereotaxic frame. This allowed(More)
PURPOSE We report a case of corneal warpage secondary to hydrogel lens wear that was initially mistaken as a case of keratoconus. METHODS A 26-year-old Chinese female hydrogel lens wearer presented with an interest in refractive surgery. After topographies and pachymetries were performed, keratoconus was initially diagnosed for her right eye and suspect(More)
The 7-year-old girl presenting with cushingoid appearance and gross hematuria was found to have a right renal tumor. Preoperative hormonal assay revealed an extremely high plasma ACTH level and elevated plasma cortisol levels. Right radical nephrectomy was performed, and pathology proved the tumor to be a clear cell sarcoma, a sarcomatous variant of Wilms'(More)
PURPOSE We report a case demonstrating the importance of trial fitting before the dispensing of prescription contact lenses. METHODS The patient was an 18-year-old computer-using experienced hydrogel lens wearer who ran out of contact lens supply. The patient purchased a brand new box of daily disposable lenses from a retail store having known his back(More)
Corneal ectasia following Laser in situ keratomileussis (Lasik), a known complication can only be treated with the use of rigid gas permeable contact lens, penetrating keratoplasty or corneal cross-linking surgery. A 33 year old Asian male was diagnosed with corneal ectasia in the right eye several months after bilateral Lasik and was fitted with a rigid(More)
Ocular tissue damage because of exposure to visible light has been demonstrated by the results of human and animal studies. The short-wavelength visible light between 430 nm to 500 nm (blue light) is especially associated with retina damage. Recently, new powerful sources and relatively inexpensive blue energy of LED (light emitting diodes) family lamps in(More)
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