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We describe a method for automatically building statistical shape models from a training set of example boundaries/surfaces. These models show considerable promise as a basis for segmenting and interpreting images. One of the drawbacks of the approach is, however, the need to establish a set of dense correspondences between all members of a set of training(More)
We describe an automatic method for building optimal 3D statistical shape models from sets of training shapes. Although shape models show considerable promise as a basis for segmenting and interpreting images, a major drawback of the approach is the need to establish a dense correspondence across a training set of example shapes. It is important to(More)
Osteoarthritis is the most common cause of disability in the developed world. One the most important features of the disease is the progressive thinning and eventual loss of articular cartilage which can be visualised using Magnetic Resonance (MR) imaging. A major goal of research in osteoarthritis is the discovery and development of drugs which preserve(More)
Measurements of apparent diffusion coefficient (ADC) using magnetic resonance imaging (MRI) have been suggested as potential imaging biomarkers for monitoring tumor response to treatment. However, conventional pulsed-gradient spin echo (PGSE) methods incorporate relatively long diffusion times, and are usually sensitive to changes in cell density and(More)
Magnetic resonance imaging (MRI) is emerging as the method of choice for measuring cartilage loss in osteoarthritis (OA), but current methods of analysis are imperfect for therapeutic clinical trials. In this paper, we present and evaluate, in two multicenter multivendor studies, a new method for anatomically corresponded regional analysis of cartilage(More)
Degeneration and loss of articular cartilage in Osteoarthritis (OA) is difficult to measure, because changes are small and localised. We present a method that uses statistical shape models of the knee bones to define an anatomically consistent frame of reference across a population, providing sensitive measures of cartilage morphology in anatomically(More)
The objective of this work is to examine the feasibility of a method to register dynamic contrast enhanced computed X-ray tomography (DCE-CT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) datasets in order to make possible the comparison of parametric maps generated from tracer kinetic modeling. First, the CT and MR dynamic sets were(More)