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BACKGROUND Avida is a computer program that performs evolution experiments with digital organisms. Previous work has used the program to study the evolutionary origin of complex features, namely logic operations, but has consistently used extremely large mutational fitness effects. The present study uses Avida to better understand the role of low-impact(More)
The H1N1 influenza A virus has been circulating in the human population for over 95 years, first manifesting itself in the pandemic of 1917–1918. Initial mortality was extremely high, but dropped exponentially over time. Influenza viruses have high mutation rates, and H1N1 has undergone significant genetic changes since 1918. The exact nature of H1N1(More)
1. Abstract Genetic change at the level of the population usually occurs too slowly to be studied in sufficient detail in nature, which is why population geneticists primarily rely upon theoretical studies, using either mathematical modeling or numerical simulations. Studying population change on a theoretical level is challenging because so many components(More)
BACKGROUND It is increasingly evident that there are multiple and overlapping patterns within the genome, and that these patterns contain different types of information--regarding both genome function and genome history. In order to discover additional genomic patterns which may have biological significance, novel strategies are required. To partially(More)
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