John C. Chen

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Magnetic resonance (MR) imaging with a whole-body imager was performed in 10 fresh, unfixed whole human brains selected randomly from cadavers. All subjects were neurologically intact before death. T2 time constants were measured within the caudate nucleus, putamen, globus pallidus, cortical gray matter, subcortical white matter, and optic radiation. These(More)
PURPOSE Intravitreal ranibizumab injections currently are the standard treatment for neovascular age-related macular degeneration (AMD). However, a broad range of response rates have been observed, the reasons for which are poorly understood. This pharmacogenetic study evaluated the impact of high-risk alleles in CFH, ARMS2, VEGFA, vascular endothelial(More)
OBJECTIVE The aim of the study was to investigate the role of single-nucleotide polymorphisms (SNPs) located in the neuropilin-1 (NRP1) gene in treatment response to antivascular endothelial growth factor (VEGF) therapy for neovascular age-related macular degeneration (nvAMD). METHODS Four SNPs in the NRP1 gene (rs2229935, rs2247383, rs2070296, and(More)
Mission Statement To impart knowledge in the art and science of mechanical engineering through a comprehensive curriculum true to the traditional Cal Poly learn-by-doing philosophy that produces mechanical engineers of high ethics and skill, fully prepared for entry into industry, government, graduate school and private enterprise. Program Educational(More)
A randomized, prospective clinical trial of 70 patients undergoing craniotomy was performed to compare and evaluate two forms of mechanical prophylaxis of deep vein thrombosis. Thirty-eight patients received antiembolism stockings, whereas 32 patients received external pneumatic compression. Prophylaxis was begun preoperatively and continued(More)
BACKGROUND The purpose of this study was to evaluate the real-world use, efficacy, and safety of one or more dexamethasone intravitreal implant(s) 0.7 mg (DEX implant) in patients with macular edema (ME). METHODS This was a retrospective cohort study of patients with ME secondary to retinal disease treated at ten Canadian retina practices, including one(More)
  • Jonathan Charles White, Russell V Westphal, John Chen, Tina Jameson, Drew Hutcheson, Rocky Ulk +2 others
  • 2011
This thesis presents the design and implementation of a high-frame-rate oil film interferometry technique (HOFI) used to directly measure skin friction in time dependent flows. Experiments were performed to determine the ability of a high-speed camera to capture oil film interferometry images. HOFI was found to be able to capture these interferometry images(More)