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PURPOSE To validate known and determine new predictors of non-response to ranibizumab in patients with neovascular age-related macular degeneration (AMD) and to incorporate these factors into a prediction rule. METHODS This multicenter, observational cohort study included 391 patients treated with ranibizumab for neovascular AMD. We performed genetic(More)
A B S T R A C T Vibrothermography, or sonic IR, is a nondestructive evaluation technique used to find surface and near surface defects—such as cracks and delaminations—through observations of vibration-induced heat generation. This method has significant interest as an industrial inspection method, however, a lack of understanding of the fundamental physics(More)
Students' development of self-directed and lifelong learning capacities is vital for their success in today's engineering environment. Instructors play a critical role in influencing outcomes related to self-directed learning (SDL) through their design of courses that support students' transitions from controlled to autonomous learning behaviors. Yet there(More)
CONTEXT Inflammation and ischemia-reperfusion injury during coronary artery bypass graft (CABG) surgery requiring cardiopulmonary bypass are associated with postoperative myocardial infarction (MI) and mortality. OBJECTIVE To determine the efficacy and safety of pexelizumab, a C5 complement inhibitor, in reducing perioperative MI and mortality in CABG(More)
OBJECTIVE To assess the health economic impact of perioperative myocardial infarction in a cohort of patients undergoing coronary artery bypass graft surgery. DESIGN Retrospective cohort analysis using data from hospital bills and uniform billing forms. SETTING A total of 147 geographically diverse hospitals in the United States. PATIENTS The study(More)
BACKGROUND During cardiac surgery requiring cardiopulmonary bypass, pro-inflammatory complement pathways are activated by exposure of blood to bio-incompatible surfaces of the extracorporeal circuit and reperfusion of ischemic organs. Complement activation promotes the generation of additional inflammatory mediators thereby exacerbating tissue injury. We(More)
BACKGROUND AND PURPOSE Pharmacological modulation of complement activation recently has been postulated as a therapeutic target in the treatment of neurological injury. We hypothesized that pexelizumab, a humanized scFv monoclonal antibody directed against the C5 complement component, would limit deficits in patients undergoing coronary artery bypass graft(More)
PURPOSE Intravitreal ranibizumab injections currently are the standard treatment for neovascular age-related macular degeneration (AMD). However, a broad range of response rates have been observed, the reasons for which are poorly understood. This pharmacogenetic study evaluated the impact of high-risk alleles in CFH, ARMS2, VEGFA, vascular endothelial(More)