John Blundell

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The Behavioral Satiety Sequence (BSS) is the name given to the orderly transitions of eating, activity grooming and resting measured during the postingestive period. Because the BSS is considered to reflect the operations of natural physiological processes underlying satiety, the sequence can be used to discriminate between different drugs (and other(More)
OBJECTIVE To examine the effects of exercise on short term energy intake and to investigate the existence of exercise-induced anorexia. DESIGN Two studies were conducted, both with three treatment conditions and employing a repeated measures design. SETTING The Human Appetite Research Unit at Leeds University Psychology department. SUBJECTS Twenty(More)
This present paper reviews the reliability and validity of visual analogue scales (VAS) in terms of (1) their ability to predict feeding behaviour, (2) their sensitivity to experimental manipulations, and (3) their reproducibility. VAS correlate with, but do not reliably predict, energy intake to the extent that they could be used as a proxy of energy(More)
Objective:To identify and characterize the individual variability in compensation for exercise-induced changes in energy expenditure (EE).Design:Twelve-week exercise intervention.Subjects:Thirty-five overweight and obese sedentary men and women (body mass index, 31.8±4.1 kg m−2; age, 39.6±11.0 years) were prescribed exercise five times per week for 12 weeks(More)
CONTEXT The magnitude of exercise-induced weight loss depends on the extent of compensatory responses. An increase in energy intake is likely to result from changes in the appetite control system toward an orexigenic environment; however, few studies have measured how exercise impacts on both orexigenic and anorexigenic peptides. OBJECTIVE The aim of the(More)
At a time of increased obesity, decreased physical activity, and high food consumption, the relationship between physical activity and appetite control needs to be examined. Many people believe that the energy expended as a result of physical activity generates a drive to eat. However, a counterintuitive conclusion arises since there is no compelling(More)
Cannabinoid 1 receptor (CB1R) inverse agonists are emerging as a potential obesity therapy. However, the physiological mechanisms by which these agents modulate human energy balance are incompletely elucidated. Here, we describe a comprehensive clinical research study of taranabant, a structurally novel acyclic CB1R inverse agonist. Positron emission(More)
Three separate experiments in lean subjects confirmed that a 1.52-MJ (362-kcal) carbohydrate supplement at breakfast suppressed appetite 90 min later but had no effect on a test meal given after 270 min. A 1.52-MJ (362-kcal) fat supplement produced no detectable action on measures of appetite at any time point. Therefore, fat and carbohydrate do not have(More)
Although, as described elsewhere in this report, the consumption of particular nutrients can modify behaviors that are not directly related to eating, it seems highly likely that the main function of nutrient-induced changes in neurotransmitter synthesis is to provide the brain with information about what has been eaten, which the brain can then utilize in(More)
Many people experience great difficulty in preventing energy intake from outstripping energy expenditure. Eating high-fat foods can facilitate the development of short-term positive energy balances by influencing satiation and satiety, the processes that control the size of eating episodes and the strength of postingestive appetite inhibition, respectively.(More)