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In vertebrate animals, fibrillar collagen accumulates, organizes, and persists in structures which resist mechanical force. This antidissipative behavior is possibly due to a mechanochemical force-switch which converts collagen from enzyme-susceptible to enzyme-resistant. Degradation experiments on native tissue and reconstituted fibrils suggest that(More)
Mechanical strain or stretch of collagen has been shown to be protective of fibrils against both thermal and enzymatic degradation. The details of this mechanochemical relationship could change our understanding of load-bearing tissue formation, growth, maintenance, and disease in vertebrate animals. However, extracting a quantitative relationship between(More)
  • C D 'arcangues, P D Griffin, H Von Hertzen, K M Vogelsong, M Mbizvo, E Vayena +229 others
  • 2002
INTRODUCTION In 1995, approximately 570 million couples worldwide regularly used a method of family planning. Because use does not necessarily mean acceptance, this statistic offers only a glimpse at the behaviours that determine a couple's decision to use a method of fertility regulation. Nearly half the users of a reversible method discontinue its use(More)
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