John B. Nelson

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Erectile dysfunction (ED) is frequently associated with injury to the cavernous nerve sustained during pelvic surgery. Functional recovery from cavernous nerve injury is generally incomplete and occurs over an extended time frame. We employed a therapeutic gene transfer approach with herpes simplex virus (HSV) vector expressing glial cell line-derived(More)
Neurturin (NTN), a member of glial cell line-derived neurotrophic factor (GDNF) family, is known as an important neurotrophic factor for penis-projecting neurons. We recently demonstrated significant protection from erectile dysfunction (ED) following a replication-defective herpes simplex virus (HSV) vector-mediated GDNF delivery to the injured cavernous(More)
The experiments reported in the preceding paper had indicated t h a t A ctinobacillus muris and Brucella bronchiseptica were of no direct significance in the etiology of infectious catarrh, the disease being maintained for m a n y passages in their absence (1). Attempts to reproduce it by the nasal instillation of other bacteria cultivable from the middle(More)
Earlier work on mouse hepatitis 1 had indicated that different strains of mice varied markedly in their susceptibility to the disease3 Based on the mortality rate of infected weanlings Princeton mice were the most susceptible (98 per cent) and Swiss mice the least so (4 per cent) of the strains that were tested in significant numbers. Since the causal virus(More)
The spontaneous appearance of a second paratyphoid infection in a guinea pig population during the endemic stage of an earlier epidemic is reported. A comparative study of the gross pathology of the two infections indicated a difference in the loci of development of the respective organisms in the animal host. The two types were readily differentiated by(More)