John B Mumm

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Interleukin-10 (IL-10) is a multifunctional cytokine that exerts potent context specific immunostimulatory and immunosuppressive effects. We have investigated the mechanism by which PEGylated rIL-10 regulates plasma cholesterol in mice and humans. In agreement with previous work on rIL-10, we report that PEGylated rIL-10 harnesses the myeloid immune system(More)
A limited amount of T cells, notably CD8 + cytotoxic T lymphocytes (CD8 + CTLs), can infiltrate human tumors. 1 However, thanks to extensive research performed over several decades, the isolation of tumor-associated antigen (TAA)-specific CD8 + CTLs, as they develop in many cancer patients, has become possible. This implies that, far from being completely(More)
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