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BACKGROUND Understanding how complex antibiotics are synthesised by their producer bacteria is essential for creation of new families of bioactive compounds. Thiomarinols, produced by marine bacteria belonging to the genus Pseudoalteromonas, are hybrids of two independently active species: the pseudomonic acid mixture, mupirocin, which is used clinically(More)
Mutation of the HMG-CoA synthase encoding mupH gene in Pseudomonas fluorescens gives rise to a new metabolite formed from a truncated polyketide intermediate, providing in vivo evidence for the roles of mupH and cognate genes found in several "AT-less" and other bacterial PKS gene clusters responsible for the biosynthesis of diverse metabolites containing(More)
  • Gurdip Bakshia, Fousseni Chabi-Yob, +12 authors Zhaogang Song
  • 2015
How reliable is the recovery theorem of Ross (2015)? We explore this question in the context of options on the 30-year Treasury bond futures, allowing us to deduce restrictions that link the risk-neutral and physical distributions. The backbone of these restrictions is that the martingale component of the stochastic discount factor is unity. Our approach(More)
This document is an on-line supplement to a recent paper (Carr and Crosby (2008)) entitled " A class of Lévy process models with almost exact calibration to both barrier and vanilla FX options ". This document is an on-line supplement to Carr and Crosby (2008). Section 2 describes some of the details of the numerical implementation of the algorithms in Carr(More)
We develop an incomplete markets framework to show that international risk sharing can be low, particularly among countries with large interest-rate differentials. Furthermore, risk sharing computed from asset returns can be consistent with that computed from consumption. The fundamental departure in our paper is that exchange rate growth need not equal the(More)
paper presents preliminary findings and is being distributed to economists and other interested readers solely to stimulate discussion and elicit comments. The views expressed in this paper are those of the authors and are not necessarily reflective of views at the Federal Reserve Bank of New York or the Federal Reserve System. Any errors or omissions are(More)
athlete, the thought of completing strenuous exercise like running 26.1 miles or pitching a baseball game while suffering from asthma is almost unthinkable. Having taken up yoga recently , I am keenly aware of the power and importance of deep breathing in a fitness routine. It almost goes without saying that breathing is fundamental not only to athletes,(More)
Polyketide metabolites produced by bacteria and other organisms include antibiotics, anticancer and antifungal compounds. In type II polyketide synthesis, three enzymes are sufficient to form a polyketide product of the requisite chain length, although the fidelity of the first cyclization is variable. Addition of ketoreductase (KR) to this system results(More)
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