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Papillomaviral E2 genes encode proteins that regulate viral transcription. While the full-length bovine papillomavirus type 1 (BPV-1) E2 peptide is a strong trans activator, the homologous full-length E2 product of human papillomavirus type 16 (HPV-16) appeared to vary in function in previous studies. Here we show that when expressed from comparable(More)
OBJECT A gene contributing to the autosomal-dominant cerebral cavernous malformation (CCM) phenotype, KRIT1 (an acronym for Krev Interaction Trapped 1), has been identified through linkage analysis and mutation screening. The authors collected blood samples from 68 patients with familial CCM and 138 patients with apparently sporadic CCM as well as from(More)
Primitive neuroectodermal tumors (PNET) originating within the spinal cord are extraordinarily rare. We report a female who presented at age 21 with diffuse involvement of the lower spinal cord. After biopsy and successful treatment with radiation and chemotherapy, she recurred 10 years later with disease in her cerebellum. She was reinduced with(More)
The results of this study show that the kinetic parameters obtained for the EGF-R on A431 cells by Cytostar-T plate are compatible with those obtained by SPA and filtration methods. Total cpm measured are lower on Cytostar-T compared to SPA due to differences in counting efficiency but competition curves and IC values were virtually identical across the(More)
Charcot joints of the spine are rare entities which mimic low grade soft tissue malignancies by appearing as a destructive mass lesion on radiographic studies. We report a 42-year-old diabetic female, who presented with a mass-like lesion of the thoracic spine extending into the posterior mediastinum. She presented with hemiplegia. With conservative(More)