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CONTEXT Defined as the loss of ovarian function within 5 yr of diagnosis, acute ovarian failure (AOF) is known to develop in a subset of survivors of pediatric and adolescent cancers. Its precise incidence is unknown, and data concerning its risk factors are limited. OBJECTIVE Our objective was to determine the incidence of and patient/treatment factors(More)
These studies were undertaken to determine the effect, if any, of treatment for cancer diagnosed during childhood or adolescence on ovarian function and reproductive outcomes. We reviewed the frequency of acute ovarian failure, premature menopause, live birth, stillbirth, spontaneous and therapeutic abortion and birth defects in the participants in the(More)
STUDY OBJECTIVE To examine the prevalence of and risk factors for fatigue and sleep disturbance among adult survivors of childhood cancer. DESIGN Retrospective cohort of childhood cancer survivors. SETTING Twenty-six academic institutions treating childhood cancer. PARTICIPANTS Two thousand six hundred forty-five survivors of childhood acute(More)
OBJECTIVE This study was undertaken to determine the effect, if any, of prior treatment with radiation therapy or chemotherapy for cancer diagnosed during childhood or adolescence on pregnancy loss, live births, and birth weight. STUDY DESIGN We reviewed pregnancy outcome among female participants in the Childhood Cancer Survivor Study (CCSS) who returned(More)
PURPOSE To evaluate and compare psychological outcomes in long-term survivors of pediatric brain cancer and siblings of childhood cancer survivors, and to identify significant correlates of psychological distress. METHODS One thousand one hundred one adult survivors of childhood brain cancer and 2,817 siblings completed a long-term follow-up questionnaire(More)
BACKGROUND The objective of the current report was to compare the self-reported rates of special education (SE) and educational attainment among specific groups of childhood cancer survivors and a random sample of sibling controls. METHODS The Childhood Cancer Survivor Study is a retrospective cohort of individuals who were diagnosed with a cancer in(More)
Treatment for Hodgkin's disease (HD) is associated with a variety of thyroid abnormalities, including hypothyroidism, hyperthyroidism, and thyroid neoplasms. Due to the small sample size and short follow-up time of most published studies, it has been difficult to appreciate the full extent of the problem and to characterize the interaction between various(More)
BACKGROUND Improved survival after childhood cancer raises concerns over the possible long-term reproductive health effects of cancer therapies. We investigated whether children of female childhood cancer survivors are at elevated risk of being born preterm or exhibiting restricted fetal growth and evaluated the associations of different cancer treatments(More)
PURPOSE To examine the determinants of smoking behavior among participants in the Childhood Cancer Survivors Study (CCSS). METHODS This retrospective cohort survey study was conducted among 9,709 childhood cancer survivors. Main outcomes included smoking initiation and cessation. RESULTS Twenty-eight percent of patients reported ever smoking and 17%(More)
BACKGROUND Childhood cancer survivors who retain ovarian function after completing cancer treatment are at increased risk of developing premature menopause, defined as cessation of menses before age 40 years. However, published data pertaining to the risk and frequency of premature menopause are limited. METHODS We assessed the incidence of and risk(More)