John A. Rose

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Rapid modulation of hippocampal synaptic plasticity by estrogen has long been a hot topic, but analysis of molecular mechanisms via synaptic estrogen receptors has been seriously difficult. Here, two types of independent synaptic plasticity, long-term depression (LTD) and spinogenesis, were investigated, in response to 17beta-estradiol and agonists of(More)
Nitric oxide (NO) is a gaseous neuromessenger. Although increasing evidence reveals significant physiological effects of NO in the hippocampal synaptic plasticity, the spatial distribution of NO production has remained largely uncharacterized due to the poor development of techniques for real-time NO imaging. In this work, using a NO-reactive fluorescent(More)
We explore the information processing capabilities and ef-ciency of DNA computations by giving two diierent types of implementations of nite-state machines. A ligation-based approach allows input of arbitrary length and can be readily implemented with current biotechnology, but requires sequential input feed and diierent molecules for diierent machines. In(More)