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BACKGROUND Autosomal dominant inheritance of germline mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene are a major risk factor for pulmonary arterial hypertension (PAH). While previous studies demonstrated a difference in severity between BMPR2 mutation carriers and noncarriers, it is likely disease severity is not equal among BMPR2(More)
BACKGROUND Embryo retention in the Fallopian tube (FT) is thought to lead to ectopic pregnancy (EP), a considerable cause of morbidity. In mice, genetic/pharmacological silencing of cannabinoid receptor Cnr1, encoding CB1, causes retention of embryos in the oviduct. The role of the endocannabinoids in tubal implantation in humans is not known. METHODS AND(More)
BACKGROUND Idiopathic pulmonary fibrosis is progressive and often fatal; causes of familial clustering of the disease are unknown. Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase and telomerase RNA, respectively, cause autosomal dominant dyskeratosis congenita, a rare hereditary disorder associated with premature(More)
RATIONALE Serotonin is a pulmonary vasoconstrictor and smooth muscle cell mitogen. The serotonin transporter (SERT) is abundant in pulmonary vascular smooth muscle. Compared with the short (S) allele, the long (L) SERT promoter allele is associated with increased SERT transcription and more severe pulmonary hypertension in a cohort of patients with chronic(More)
Male Leiocephalus carinatus exhibited five types of aggressive displays, two of which were used to quantify aggression in paired encounters. After the dominant and subordinate lizard were identified, the area over parietal eye/pineal gland of the latter was shielded. This resulted in the subordinate lizard selecting higher body temperatures, exhibiting more(More)
BACKGROUND While BMPR2 mutation strongly predisposes to pulmonary arterial hypertension (PAH), only 20% of mutation carriers develop clinical disease. This finding suggests that modifier genes contribute to FPAH clinical expression. Since modifiers are likely to be common alleles, this problem is not tractable by traditional genetic approaches. Furthermore,(More)
Growth rates, resource use, and ontogeny of behavior patterns were examined in captive groups of juvenile green iguanas (Iguana iguana). Four groups were housed in large arenas where supplemental heat and perch sites were limited, whereas two control groups were housed in similar arenas without limited resources. Growth, frequency and types of displays,(More)
For 1 year, groups of juvenile male green iguanas (Iguana iguana) were housed such that one group was visually exposed to an adult female, a second group was both visually and chemically exposed to an adult female, a third group was visually exposed to an adult male, and a fourth group was both visually and chemically exposed to an adult male. Juvenile(More)
The telomerase reverse transcriptase synthesizes new telomeres onto chromosome ends by copying from a short template within its integral RNA component. During telomere synthesis, telomerase adds multiple short DNA repeats successively, a property known as repeat addition processivity. However, the consequences of defects in processivity on telomere length(More)
Dyskeratosis congenita (DC) is a premature ageing syndrome characterised by short telomeres. An X-linked form of DC is caused by mutations in DKC1 which encodes dyskerin, a telomerase component that is essential for telomerase RNA stability. However, mutations in DKC1 are identifiable in only half of X-linked DC families. A four generation family with(More)