John A. Little

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A comparison of six similarity measures for use in intensity-based two-dimensional-three-dimensional (2-D-3-D) image registration is presented. The accuracy of the similarity measures are compared to a "gold-standard" registration which has been accurately calculated using fiducial markers. The similarity measures are used to register a computed tomography(More)
In image-guided surgery it is necessary to align preoperative image data with the patient. The rigid-body approximation is usually applied, but is often not valid due to tissue deformation. Non-rigid deformation algorithms have been applied to related, but not identical problems, such as atlas matching and surgery simulation. In image-guided surgery we have(More)
We have used a twelve degrees of freedom global affine registration technique incorporating a multiresolution optimisation of mutual information to register MR and CT images with uncertain voxel dimensions and CT gantry tilt. Visual assessment indicates improved accuracy, without loss of robustness compared to rigid body registration.
BACKGROUND The pig is an accepted species for evaluating the safety of molecules in dermal wound healing indications; however, the sizes of wounds assessed have not always been comparable to large incisions encountered clinically. OBJECTIVE To develop a clinically relevant model of incisional wounding in the Göttingen minipig for assessing the safety and(More)
Multiple sources of 3D medical image data can be used to construct detailed patient representations. Typically registration is achieved assuming the validity of rigid body transformation. In many applications, and in particular when updating representations used for guidance during surgery and therapeutic interventions, this assumption is inappropriate. In(More)
Juvista™ drug product contains human recombinant active transforming growth factor beta 3 (TGFβ3; avotermin). Juvista is being developed for the prevention and reduction of human scarring. Phase II and III clinical and development batches of Juvista were assayed for content by an immunoenzymometric assay (IEMA) using a National Institute for Biological(More)