John A. Garcia

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PURPOSE To evaluate the spatial relationship between peritumoral edema and recurrence pattern in patients with glioblastoma (GBM). METHODS AND MATERIALS Forty-eight primary GBM patients received three-dimensional conformal radiotherapy that did not intentionally include peritumoral edema within the clinical target volume between July 2000 and June 2001.(More)
PURPOSE To conduct a clinical trial evaluating adaptive head and neck radiotherapy (ART). METHODS Patients with locally advanced oropharyngeal cancer were prospectively enrolled. Daily CT-guided setup and deformable image registration permitted mapping of dose to avoidance structures and CTVs. We compared four planning scenarios: (1) original IMRT plan(More)
PURPOSE To investigate the dosimetry and feasibility of carotid-sparing intensity-modulated radiotherapy (IMRT) for early glottic cancer and to report preliminary clinical experience. METHODS AND MATERIALS Digital Imaging and Communications in Medicine radiotherapy (DICOM-RT) datasets from 6 T1-2 conventionally treated glottic cancer patients were used to(More)
Fifty-nine dairy cows with left displacement of the abomasum were randomly assigned to receive 1 of 2 treatments. Twenty-eight were treated by right paramedian abomasopexy via laparotomy, and 31 were treated by percutaneous fixation of the abomasum, using the bar suture or toggle pin technique. Comparisons of the 2 groups, at 4 follow-up examinations,(More)
PURPOSE High cure rates for Hodgkin's lymphoma must be balanced with long-term treatment-related toxicity. Here we report an intensity-modulated radiation therapy (IMRT) technique that achieves adequate target coverage for mediastinal disease while minimizing high- and low-dose exposure of critical organs. METHODS AND MATERIALS Treatment plans for IMRT(More)
Abstract Purpose – The purpose of this paper is to identify key performance indicators (KPIs) and categorize them based on specific aspects of facility performance measurement in order to facilitate a holistic performance assessment. Design/methodology/approach – A qualitative approach, based on the literature, is adopted. This approach relies on an(More)
PURPOSE To evaluate the potential of three-dimensional proton beam therapy (3D-PBT) for reducing doses to normal structures in patients with mediastinal lymphomas compared with conventional photon radiation therapy (RT). METHODS AND MATERIALS We treated 10 consecutive patients with mediastinal masses from lymphomas with 3D-PBT between July 2007 and(More)
BACKGROUND A variant of basal cell carcinoma (BCC) with scattered large, pleomorphic cells has previously been reported as "basal cell epithelioma with giant tumor cells" and "basal cell carcinoma with monster cells." OBJECTIVE Our purpose was to describe the clinical, histologic, and DNA ploidy findings in BCCs with these cytologic features. METHODS(More)
PURPOSE Early-stage Hodgkin lymphoma (HL) is a rare disease, and the location of lymphoma varies considerably between patients. Here, we evaluate the variability of radiation therapy (RT) plans among 5 International Lymphoma Radiation Oncology Group (ILROG) centers with regard to beam arrangements, planning parameters, and estimated doses to the critical(More)
PURPOSE Bleb leaks after trabeculectomy with antimetabolites can be recalcitrant to therapy. Peribleb autologous blood injections are a moderately successful new treatment modality for such leaks. However, it is unclear what mechanism the injections work to achieve leak resolution. METHODS A randomized, prospective study in the rabbit model was undertaken(More)