John A Engler

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Excitatory synapses are located on actin-rich protrusions known as dendritic spines. alpha-Actinin is an actin binding protein enriched in the postsynaptic density (PSD) of excitatory synapses. Because it also binds to NMDA receptors and other PSD components, alpha-actinin has been proposed to link NMDA receptors and the PSD to the underlying actin(More)
We have proposed that N-acetylaspartylglutamate (NAAG) or its hydrolytic product glutamate, is a chemical signaling agent between axons and periaxonal glia at non-synaptic sites in crayfish nerves, and that glutamine is a probable precursor for replenishing the releasable pool of NAAG. We report here, that crayfish central nerve fibers synthesize NAAG from(More)
First measurements with a prototype ionization chamber are described to be applied in online monitoring of modulated fields in radiation therapy. The liquids isooctane, isononane (TMP) and tetramethylsilane (TMS) are used in a high purity grade in order to realize high current signals for electronic read-out in parallel at frequencies exceeding 10 Hz.(More)
Glutaminase of crayfish axons is believed to participate in recycling of axon-glia signaling agent(s). We measured the activity and properties of glutaminase in crude homogenates of crayfish CNS, using ion exchange chromatography to separate radiolabeled product from substrate. Crayfish glutaminase activity is cytoplasmic and/or weakly bound to membranes(More)
Rupture of isolated posterior spinal artery (PSA) aneurysms is a rare cause of subarachnoid hemorrhage (SAH) that presents unique diagnostic challenges owing to a nuanced clinical presentation. Here, we report on the diagnosis and management of the first known case of an isolated PSA aneurysm in the context of leukocytoclastic vasculitis. A 53-year-old male(More)
Plantar hyperhydrosis is a disabling condition of excessive, symmetric, focal sweating of the feet with social, psychological, and medical implications. Treatment options include topical agents, iontophoresis, botulinum toxin injection, and surgical disruption of the lumbar sympathetic chain. Surgical corridors include transperitoneal and retroperitoneal(More)
PAPER Sabaté et al. Fuel cell-powered microfl uidic platform for lab-on-a-chip applications Fabricating biohybrid cantilevers and actuators with hydrogels and cardiac cells using a 3D stereolithographic printer. The multi-material capability of the printer can be used to change the synthetic material composition or insert cells and proteins at precise(More)
  • K E Kadler, D F Holmes, J A Trotter, J A Chapman, G Fields, H Van Wart +28 others
  • 2004
that can become rate-limiting. The activation energy for fibril digestion (101 kcal mol –1) was found to be 4 times that of a helical collagen monomer (26). The high energy of activation for collagenolysis is in good agreement , however, with the apparent energy of activation for collagen fibril unfolding (124 kcal mol –1) measured more recently (27). We(More)
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