John A Daubenspeck

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STUDY OBJECTIVE To examine the effects of targeted inspiratory muscle training on respiratory muscle function, clinical ratings of dyspnea, and perception of resistive loads in symptomatic patients with chronic obstructive pulmonary disease. DESIGN Randomized, placebo-controlled trial with an 8-week treatment period. SETTING Outpatient pulmonary clinic(More)
To investigate the hypothesis that clinical methods and psychophysical testing provide different information about breathlessness, we compared dyspnea ratings from a modified Medical Research Council (MRC) scale, the Oxygen-Cost Diagram (OCD), and the Baseline Dyspnea Index (BDI) with the perceived magnitude of added loads in 24 patients with obstructive(More)
It has been widely recognized and previously reported that electrical fields from facial muscle electromyographic (EMG) activity can contaminate the electroencephalogram (EEG), even when closely spaced, bipolar electrode configurations are used (personal observations). We suspected that EEG signals evoked in response to pressure changes in the upper airway(More)
Breathing pattern responses to small mechanical loads added pseudorandomly to the external airway of human subjects were measured using flow-resistive and elastic loads above and below the threshold for detectability of some subjects. The zeroth lag of the computed cross-correlations between the loading sequence and the various aspects of the breathing(More)
The pattern of respiratory movements of the vocal cords in relation to airflow and respiratory system resistance was assessed in healthy human volunteers during quiet breathing. Motion pictures of the vocal cords were obtained through a fiber-optic laryngoscope inserted transnasally under topical anesthesia. A simultaneous estimate of lung volume was(More)
We have developed an intraoral bipolar surface electrode for the genioglossus muscle. The electrode, made from an athletic mouthguard and dental impression material, was fitted to the lower teeth. Electrode wires, bared at the tip, were positioned on the bottom of the mouthpiece to lie in contact with the superior surface of the genioglossus just behind the(More)
Hypoxia causes arousal. Therefore, we hypothesized that hypoxia activates the human somatomotor system and should augment tremor. We determined the effects of hypoxia, PET(O2) = 45+/-2.2 mm Hg, hypocapnia, and the hypocapnic-hypoxic interaction on finger tremor during elastic loading. A total of 12 healthy male volunteers were studied during five(More)
In this study, the respiratory related evoked responses (RREPs) from ten normal subjects in response to brief varying pressure pulses at —6, —10 and —17cm H2O with a duration of 200 ms were recorded to investigate how mid-latency cortical evoked potentials measured on the scalp are affected in response to pressure pulses of varying magnitude at the mouth.(More)
Respiratory-related evoked potentials (RREPs) were stimulated by brief (200-ms) oral pressure pulses (-10 cmH(2)O) applied at the onset of inspiration in 12 subjects. Scalp potentials were measured at 30 sites on a rectangular grid that encompassed the right side of the scalp overlying the somatosensory cortex (SSC). Concurrent and significant masseter EMG(More)
Pet-1(-/-) mice with a prenatal, genetically induced loss of 5-hydroxytryptamine (5-HT, serotonin) neurones are compromised in their ability to withstand episodic environmental anoxia via autoresuscitation. Given the prenatal role of 5-HT neurones in the development of neural networks, here we ask if a postnatal loss of 5-HT neurones also compromises(More)