John A. Biesemeier

Learn More
Decabromodiphenyl oxide (DBDPO) is a highly effective flame retardant that is primarily used in electrical and electronic equipment with a secondary, but important, application in upholstery textiles. DBDPO, the second largest volume brominated flame retardant in use today, has undergone a wide range of toxicology tests in mammalian species with the results(More)
BACKGROUND Decabromodiphenyl ether (DecaBDE; CASRN 1163-19-5) is a flame retardant used in a variety of manufactured products. A single oral dose of 20.1 mg/kg administered to mice on postnatal day 3 has been reported to alter motor activity at 2, 4, and 6 months of age. METHODS To further evaluate these results, a developmental neurotoxicity study was(More)
Groups of adult male and female rats received exposure to tetrahydrofuran (THF) vapor by inhalation in acute or subchronic exposure scenarios. Acute exposure concentrations were 0, 500, 2500, or 5000 ppm for 6 hr. Evaluations conducted immediately after exposure included clinical observations, motor activity assessments (MA), and a battery of functional(More)
Modern fire-fighting techniques, equipment and fire-resistant building design has lead to less destruction than in the previous centuries. However, a high fuel load in either a residence or a commercial building can overwhelm even the best firefighters or building construction, and factors affecting the fuel load have changed in recent decades. The fire(More)
Zhang et al. (2011) evaluated the absorption and distribution f decabromodiphenyl ether (BDE-209; CASRN 1163-19-5) when dministered to rats during gestation and lactation, and the resultng levels of BDE-209 and ‘metabolites’ in the dams and offspring. hough the authors’ concluded their “. . .results provide a basis or understanding the possible adverse(More)
Harley et al. (2010) reported that as serum concentrations of BDE‐47, BDE‐99, BDE‐100, and BDE‐153 [polybrominated diphenyl ether (PBDE) congeners] increased, the time to achieve conception also increased (Harley et al. 2010). Although PBDE con‐ centrations in serum were measured only near the end of the second trimester of pregnancy, the authors reported(More)