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Role of J Chain in Secretory Immunoglobulin Formation
TLDR
The joining (J) chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM, and both the J chain and the pIgR/SC are key proteins in secretory immunity. Expand
A Peptide‐Binding Assay for the Disease‐Associated HLA‐DQ8 Molecule
TLDR
A biochemical peptide‐binding assay for the type I diabetes‐associated DQ8, i.e. DQ (α1*0301, β1*0302), molecule is reported, which showed a different pattern of peptide binding compared to a previously studied DQ2 molecule. Expand
3-Pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing.
TLDR
The synthesis of the 3-pyrazolone bioisosteres of alpha-AA is reported, which confirmed the expected regioselectivity of the reaction between methylhydrazine and alpha-acetylbutyrolactone. Expand
β-lactamase remodeling and evolution of collateral resistance in hypermutator Pseudomonas aeruginosa upon long-term antibiotic therapy
TLDR
This work unveils the evolutionary trajectory driven by hypermutators towards a multidrug resistant phenotype after years of antibiotic treatment against a formidable pathogen. Expand
FURTHER INSIGHTS INTO SINUSOIDAL ORGANIC ANION UPTAKE
Previous studies in cultured rat hepatocytes revealed that initial uptake of sulfobromophthalein (BSP) was markedly reduced upon removal of C1from the medium. In the present study, unidirectionalExpand