Johanns T A Knape

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Captopril significantly diminished the basal diastolic blood pressure and the vasopressor response to electrical stimulation of the thoracic-lumbar spinal cord in pithed normotensive rats. The reduction of the hypertensive response to electrical stimulation was more pronounced after bilateral adrenalectomy. Captopril also diminished the vasopressor response(More)
In the pithed normotensive rat the intravenous administration of increasing doses of angiotensin II caused an increase in heart rate by a maximum of 93 ± 6 beats/min. This increase in heart rate was diminished dose-dependently by the concomitant infusion of the angiotensin II analogue saralasin. It was not affected by acute bilateral adrenalectomy but(More)
The effect of functional impairment of the renin-angiotensin system on the vasoconstriction mediated by postsynaptic α1 and α2-adrenoceptors in pithed normotensive rats was studied. Selective α1-adrenoceptor stimulation was induced by intravenously administered cirazoline, whereas B-HT 920 was used as a selective agonists at α2-adrenoceptors. The(More)
The influence of the sympathetic nervous system and of its adjacent adrenoceptors in the vasoconstriction induced by angiotensin II was studied in pithed rat preparations. The vasoconstriction induced by angiotensin II in high doses was impaired by reserpine pretreatment but not by bilateral adrenalectomy. These findings suggest that part of the pressor(More)
The influence of changes in the sodium balance on angiotensin II-induced pressor responses were studied in the pithed rat preparation, which is characterized by a highly activated renin-angiotensin-aldosterone system (RAAS) with high plasma renin and angiotensin II concentrations. The pressor response to angiotensin II was enhanced by excessive sodium(More)
Vasopressin caused a potent vasoconstrictor effect in pithed rat preparations, without significantly altering heart rate. The vasopressor/constrictor response to vasopressin was not influenced by bilateral adrenalectomy, reserpine pretreatment or the prior administration of the alpha-adrenoceptor antagonists prazosin and yohimbine. The minor impairments of(More)
Human lymphocytes obtained from tonsils and peripheral blood were found to bind human fluid phase C3b, obtained by trypsin treatment. This binding was detected by indirect immunofluorescence (IIF) using specific anti-C3 antisera. Lymphocytes isolated from thymus tissue scored low percentages in IIF, indicating that the main population of thymus-derived(More)
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