Johannes Schulte-Pelkum

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Anti-SS-A (Ro52/Ro60) autoantibodies have been described as serological marker for Sjögren's syndrome but are also found in patients with other systemic autoimmune diseases. Historically, these autoantibodies were considered as a uniform autoantibody-system. However, recent studies provided evidence that Ro60 and Ro52 are not part of a stable macromolecular(More)
Autoantibodies to topoisomerase I (topo-I, also referred to as Scl-70, ATA) have historically been considered a specific marker for systemic sclerosis (SSc). Although found in approximately 20% of SSc sera, other evidence indicated that ATA also occur in up to 25% of systemic lupus erythematosus (SLE). Given that SLE is approximately 100 times more(More)
Type I hypersensitivity is driven by allergen specific immunoglobulin E (sIgE) and thus sIgE represents a marker for modern allergy diagnosis. Recently, a rapid assay for the detection of sIgE, termed as (Allergy Lateral Flow Assay) ALFA, has been developed. The objective of our study is the evaluation of a scanner-based system for the semiquantitative(More)
INTRODUCTION Autoantibodies to the ribosomal P proteins represent a highly specific marker for the diagnosis of systemic lupus erythematosus, where they have been associated with certain clinical manifestations. Historically, autoantibodies against ribosomal P proteins have been detected by indirect immunofluorescence, immunodiffusion, immunoblot, and other(More)
Antineutrophil cytoplasmic antibodies (ANCA) are the serological hallmark of some idiopathic systemic vasculitides. Besides the investigation of ANCA-associated vasculitis (AAV) and constant effort for a standardized nomenclature and classification of the AAV, a main focus of research during the last few years has been to constantly improve the performance(More)
Background. The Allergy Lateral Flow Assay (ALFA) is a novel rapid assay for the detection of sIgE to allergens. The objective of this study is the evaluation of ALFA for the detection of sIgE to bee venom (BV) and wasp venom (WV) in insect venom allergic patients. Methods. Specific IgE to BV and WV was analyzed by ALFA, ALLERG-O-LIQ, and ImmunoCAP in 80(More)
Idiopathic polymyositis is a chronic inflammatory systemic disease with preponderant infestation of the musculature. Dermatomyositis also involves skin participation (Conrad et al., 2001c; Kalovidouris, 1992; Mimori, 1996). Idiopathic, secondary and paraneoplastic forms of the disease can also be observed. The first report about myositis was given in 1863(More)
Reference 1. Mahler M, Ngo JT, Schulte-Pelkum J, Luettich T, Fritzler MJ: Limited reliability of the indirect immunofluorescence technique for the detection of anti-Rib-P antibodies. Arthritis Res Ther 2008, 10:R131. Correction Correction: Limited reliability of the indirect immunofluorescence technique for the detection of anti-Rib-P antibodies Michael(More)
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