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OBJECTIVES Liver biopsies are the current gold standard in non-alcoholic steatohepatitis (NASH) diagnosis. Their invasive nature, however, still carries an increased risk for patients' health. The development of non-invasive diagnostic tools to differentiate between bland steatosis (NAFL) and NASH remains crucial. The aim of this study is the evaluation of(More)
The nuclear lamina is the structural scaffold of the nuclear envelope and is well known for its central role in nuclear organization and maintaining nuclear stability and shape. In the past, a number of severe human disorders have been identified to be associated with mutations in lamins. Extensive research on this topic has provided novel important clues(More)
The long-acting somatostatin analogue octreotide (SMS 201-995) inhibits growth ofcertain breast cancer cell lines in vivo and in vitro. Because the antiproliferative action of octreotide depends on at least the presence of somatostatin receptors, it is crucial to determine the pattern of somatosta-tin receptor protein expression on the tumor cells. In the(More)
LINC complexes are evolutionarily conserved nuclear envelope bridges, composed of SUN (Sad-1/UNC-84) and KASH (Klarsicht/ANC-1/Syne/homology) domain proteins. They are crucial for nuclear positioning and nuclear shape determination, and also mediate nuclear envelope (NE) attachment of meiotic telomeres, essential for driving homolog synapsis and(More)
BACKGROUND LINC complexes are nuclear envelope bridging protein structures formed by interaction of SUN and KASH proteins. They physically connect the nucleus with the peripheral cytoskeleton and are critically involved in a variety of dynamic processes, such as nuclear anchorage, movement and positioning and meiotic chromosome dynamics. Moreover, they are(More)
Communication is an essential part of our daily life. A multitude of devices enable users to communicate everywhere and anytime. One drawback resulting from this ability is the expectation of a caller to always reach the callee. As a consequence the possibility to restrict "availability for communication" becomes a necessary feature too. Users demand(More)
The purpose of this study was to quantitatively measure tooth displacement under low horizontal tensile force (≤18 N) and to test the reproducibility of measurements. Anterior tooth mobility was measured using a photogrammetric measurement technique in 23 periodontally healthy subjects. While slowly increasing the tension on each tooth, an automated(More)