Learn More
The objectives of the paper presented here is the comparison of a geometry-based and voxel-based finite element (FE) method preprocessor of the human femur. The models were experimentally validated by strain gauge measurements (principal stress). The correlation coefficients (r) between the three methods (geometry-based FEM, voxel-based FEM, strain gauge(More)
The nuclear lamina is the structural scaffold of the nuclear envelope and is well known for its central role in nuclear organization and maintaining nuclear stability and shape. In the past, a number of severe human disorders have been identified to be associated with mutations in lamins. Extensive research on this topic has provided novel important clues(More)
LINC complexes are evolutionarily conserved nuclear envelope bridges, composed of SUN (Sad-1/UNC-84) and KASH (Klarsicht/ANC-1/Syne/homology) domain proteins. They are crucial for nuclear positioning and nuclear shape determination, and also mediate nuclear envelope (NE) attachment of meiotic telomeres, essential for driving homolog synapsis and(More)
BACKGROUND LINC complexes are nuclear envelope bridging protein structures formed by interaction of SUN and KASH proteins. They physically connect the nucleus with the peripheral cytoskeleton and are critically involved in a variety of dynamic processes, such as nuclear anchorage, movement and positioning and meiotic chromosome dynamics. Moreover, they are(More)
Intertrochanteric osteotomies of the proximal femur are used to improve the anatomy and function of the hip joint in a number of orthopaedic diseases. To investigate the geometrical and biomechanical aspects of pre-operative planning we created a set of programs to automatically perform a simulation of intertrochanteric osteotomies on a three-dimensional(More)
Monolayer and multilayer thin films consisting of anionic R-zirconium phosphate (R-ZrP) sheets and polycations (poly(allylamine hydrochloride) (PAH), cytochrome c) were characterized by transmission electron microscopy (TEM), ellipsometry, UV-visible absorbance spectroscopy, reflectance FT-IR, XPS, and X-ray diffraction. Titration and powder X-ray(More)