Johannes Schäfer

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Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) is an essential determinant in clathrin-mediated endocytosis (CME). In mammals three type I phosphatidylinositol-4-phosphate 5-kinase (PIPK) enzymes are expressed, with the I gamma-p90 isoform being highly expressed in the brain where it regulates synaptic vesicle (SV) exo-/endocytosis at nerve terminals.(More)
Clathrin-mediated synaptic vesicle (SV) recycling involves the spatiotemporally controlled assembly of clathrin coat components at phosphatidylinositiol (4, 5)-bisphosphate [PI(4,5)P(2)]-enriched membrane sites within the periactive zone. Such spatiotemporal control is needed to coordinate SV cargo sorting with clathrin/AP2 recruitment and to restrain(More)
We present work on the task of reducing noise in nominal terminology extraction. Based on a comparative evaluation of statistical measures aimed at capturing domain specificity, we propose strategies to increase the typically quite low accuracy of classical hybrid nominal multi-word term extraction. Our experiments on a set of German do-it-yourself(More)
We report on ongoing experiments in data extraction from German texts in the domain of do-it-yourself (DIY) instructions, where the objective is (i) to extract nominal term candidates with high quality; (ii) to extract predicate-argument structures involving the term candidates, and (iii) to relate German word formation products with syntactic paraphrases:(More)
Expanding the genetic code is an important aim of synthetic biology, but some organisms developed naturally expanded genetic codes long ago over the course of evolution. Less than 1% of all sequenced genomes encode an operon that reassigns the stop codon UAG to pyrrolysine (Pyl), a genetic code variant that results from the biosynthesis of Pyl-tRNA(Pyl). To(More)
The extraction of data exemplifying relations between terms can make use, at least to a large extent, of techniques that are similar to those used in standard hybrid term candidate extraction, namely basic corpus analysis tools (e.g. tagging, lemmatization, parsing), as well as morphological analysis of complex words (compounds and derived items). In this(More)