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The danger of luminal histamine administered orally or formed in the intestinal fluid by bacteria has long been neglected. However, the demonstration of blocking intestinal diamine oxidase (DAO) by a variety of common drugs has revived the discussion and has created a new disease concept: enteral-induced histaminosis. In an animal model the three central(More)
Diamine oxidase (DAO; EC degrades histamine and other biogenic amines [1]. D A O activity has been reported for many mammalian tissues with highest activities being found in the intestine [2]. We are interested in exploring DAO as a tool for the diagnosis and follow-up of gastrointestinal diseases associated with lesions of the intestinal mucosa as(More)
To understand the role of histamine in the aetiology and pathogenesis of human diseases reliable data are urgently needed for the histamine content and for the activities of histamine-forming and-inactivating enzymes in human tissues. In order to make a substantial progress toward this aim a tissue-sampling programme during surgical interventions was(More)
In mammalian intestine, diamine oxidase (DAO; EC is the major enzyme catabolizing histamine and other biogenic amines. In particular DAO degrades putrescine, the key metabolite of polyamine biosynthesis [1]. Since the polyamines are involved in the regulation of cell proliferation [2] we are interested in the role of DAO in this process. Using an(More)
Three hundred and forty-one drugs, commonly used in intensive care units (ICU), were chosen for an investigation of possible activation or inhibition of the histamine metabolizing enzyme diamine oxidase (DAO). After examination of 164 substances, using both canine and human DAO in anin vitro screening test, 61 agents inhibited DAO activity to various(More)
The key-enzyme for the metabolism of diamines in man is diamine oxidase (DAO). Its highest activities are in the intestinal mucosa, localized in the cytoplasm of the mature enterocytes of the small and large bowel. If the gut is affected by inflammation in Crohn's disease macroscopical changes are observed. This prospective study investigated if these(More)
For the isolation and cultivation of Legionella pneumophila from tap water in hospitals, we compared different media and selection techniques. A second part of the study compared the L. pneumophila yields from different water samples at identical sites. A total of 210 water samples (500 ml each) were collected from two selected sites in each of 21(More)
The stimulation by cholera toxin of adenylate cyclase in Chinese hamster ovarian cells could be inhibited by various ligands. The latter have been shown to contain the structural oligosaccharide entities required for binding to cholera toxin, established as Galbeta1 leads to 3GalNAcbeta1 leads to 4Gal3 comes from 2alphaNeuAc. The different inhibitory(More)
Seventy-five women who had undergone augmentation mammaplasty responded to a questionnaire that obtained their perceptions of five areas of their personal and relationship functioning: (1) body and self-image, (2) attractiveness, (3) sensual sensitivity of breasts, (4) sexual life, and (5) relationship with partner. The women's perceptions of these areas(More)
Diamine oxidase (DAO, EC degrades histamine and other biogenic amines [1]. In man, the highest activities of the enzyme are found in the kidney, intestine, and placenta [2], whereas DAO is usually below the limits of detection in human plasma. DAO activity is detectable in the circulation, however, following an intravenous administration of heparin(More)