Johannes Niediek

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The medial septum/diagonal band of Broca complex (MSDB) is a key structure that modulates hippocampal rhythmogenesis. Cholinergic neurons of the MSDB play a central role in generating and pacing theta-band oscillations in the hippocampal formation during exploration, novelty detection, and memory encoding. How precisely cholinergic neurons affect(More)
The amygdala is important for face processing, and direction of eye gaze is one of the most socially salient facial signals. Recording from over 200 neurons in the amygdala of neurosurgical patients, we found robust encoding of the identity of neutral-expression faces, but not of their direction of gaze. Processing of gaze direction may rely on a(More)
Human episodic memory refers to our ability to remember personal experiences including mentally reliving such an experience; remembering what happened; and knowing where and when it happened. Evidence from amnesic patients shows that the hippocampus is a necessary brain structure for episodic memory (Scoville and Milner, 1957). Its role in episodic memory(More)
OBJECTIVE To better understand the mechanisms that lead to the sudden and unexpected occurrence of seizures, with the neuronal correlate being abnormally synchronous discharges that disrupt neuronal function. METHODS To address this problem, we recorded single neuron activity in epilepsy patients during the transition to seizures to uncover specific(More)
Recording extracellulary from neurons in the brains of animals in vivo is among the most established experimental techniques in neuroscience, and has recently become feasible in humans. Many interesting scientific questions can be addressed only when extracellular recordings last several hours, and when individual neurons are tracked throughout the entire(More)
BACKGROUND A common problem in neurophysiology is to identify stimuli that elicit neuronal responses in a given brain region. Particularly in situations where electrode positions are fixed, this can be a time-consuming task that requires presentation of a large number of stimuli. Such a screening for response-eliciting stimuli is employed, e.g., as a(More)
The neuronal mechanisms giving rise to conscious perception remain largely elusive [1]. It is known that the strength of single-neuron activity correlates with conscious perception, especially in anterior regions of the ventral pathway in non-human primates [2-4] and in the human medial temporal lobe (MTL) [5, 6]. It is unclear, however, whether(More)
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