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The medial septum/diagonal band of Broca complex (MSDB) is a key structure that modulates hippocampal rhythmogenesis. Cholinergic neurons of the MSDB play a central role in generating and pacing theta-band oscillations in the hippocampal formation during exploration, novelty detection, and memory encoding. How precisely cholinergic neurons affect(More)
Human episodic memory refers to our ability to remember personal experiences including mentally reliving such an experience ; remembering what happened; and knowing where and when it happened. Evidence from amnesic patients shows that the hippocampus is a necessary brain structure for episodic memory (Scoville and Milner, 1957). Its role in episodic memory(More)
The amygdala is important for face processing, and direction of eye gaze is one of the most socially salient facial signals. Recording from over 200 neurons in the amygdala of neurosurgical patients, we found robust encoding of the identity of neutral-expression faces, but not of their direction of gaze. Processing of gaze direction may rely on a(More)
OBJECTIVE To better understand the mechanisms that lead to the sudden and unexpected occurrence of seizures, with the neuronal correlate being abnormally synchronous discharges that disrupt neuronal function. METHODS To address this problem, we recorded single neuron activity in epilepsy patients during the transition to seizures to uncover specific(More)
Recording extracellulary from neurons in the brains of animals in vivo is among the most established experimental techniques in neuroscience, and has recently become feasible in humans. Many interesting scientific questions can be addressed only when extracellular recordings last several hours, and when individual neurons are tracked throughout the entire(More)
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