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We study biological evolution in a high-dimensional genotype space in the regime of rare mutations and strong selection. The population performs an uphill walk which terminates at local fitness maxima. Assigning fitness randomly to genotypes, we show that the mean walk length is logarithmic in the number of initially available beneficial mutations, with a(More)
Much of the current theory of adaptation is based on Gillespie's mutational landscape model (MLM), which assumes that the fitness values of genotypes linked by single mutational steps are independent random variables. On the other hand, a growing body of empirical evidence shows that real fitness landscapes, while possessing a considerable amount of(More)
Starting from fitness correlation functions, we calculate exact expressions for the amplitude spectra of fitness landscapes as defined by Stadler [1996. Landscapes and their correlation functions. J. Math. Chem. 20, 1] for common landscape models, including Kauffman's NK-model, rough Mount Fuji landscapes and general linear superpositions of such(More)
We study biological evolution on a random fitness landscape where correlations are introduced through a linear fitness gradient of strength c. When selection is strong and mutations rare the dynamics is a directed uphill walk that terminates at a local fitness maximum. We analytically calculate the dependence of the walk length on the genome size L. When(More)
We study adaptation of a haploid asexual population on a fitness landscape defined over binary genotype sequences of length L. We consider greedy adaptive walks in which the population moves to the fittest among all single mutant neighbors of the current genotype until a local fitness maximum is reached. The landscape is of the rough mount Fuji type, which(More)
Identifying and quantifying the benefits of sex and recombination is a long-standing problem in evolutionary theory. In particular, contradictory claims have been made about the existence of a benefit of recombination on high dimensional fitness landscapes in the presence of sign epistasis. Here we present a comparative numerical study of sexual and asexual(More)
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