Johannes Matthaei

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template RNA. Other explanations, however, are fully plausible, and it is not possible at this state to rule out alternative interpretations. In the following paper, further experiments on amino acid incorporation using the system described here are presented. It will be shown that in addition to the usual requirements, the system is stimulated by template(More)
Heritability of caffeine pharmacokinetics and cytochrome P450 1A2 (CYP1A2) activity is controversial. Here, we analyzed the pharmacokinetics of caffeine, an in vivo probe drug for CYP1A2 and arylamine N-acetyltransferase 2 (NAT2) activity, in monozygotic (MZ) and dizygotic (DZ) twins. In the entire group, common and unique environmental effects explained(More)
A LTHOUGH THE FIELD OF GENETICS attained a high degree of sophistication years ago, the molecular basis of genetic information storage and retrieval lagged behind. Only within the last IO years has the chemical structure of DNA been established, mainly through the work of Chargaff et al. (3), Wilkins et al. (2g), and Watson and Crick (28). Some 8 years ago(More)
The low bioavailability of the anti-migraine drug sumatriptan is partially caused by first-pass hepatic metabolism. In this study, we analyzed the impact of the hepatic organic cation transporter OCT1 on sumatriptan cellular uptake, and of OCT1 polymorphisms on sumatriptan pharmacokinetics. OCT1 transported sumatriptan with high capacity and sumatriptan(More)
BACKGROUND Graft-derived cell-free DNA (GcfDNA), which is released into the blood stream by necrotic and apoptotic cells, is a promising noninvasive organ integrity biomarker. In liver transplantation (LTx), neither conventional liver function tests (LTFs) nor immunosuppressive drug monitoring are very effective for rejection monitoring. We therefore(More)
Genetic variation in the pharmacokinetics of metoprolol and torsemide due to polymorphisms in CYP2D6, CYP2C9, and OATP1B1 has been extensively studied. However, it is still unknown how much of the variation in pharmacokinetics of these two clinically important drugs in total is due to genetic factors. Metoprolol and torsemide were intravenously administered(More)