Johannes Manjrekar

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A facile procedure for the study of inactivation temperatures of enzymes that could be stained for activity after electrophoresis is described. This is particularly suitable for enzymes that have multiple electrophoretic forms. The results of studies on Drosophila dehydrogenases and acetylcholinesterase are presented. The procedure may be useful in the(More)
To anybody not committed to the motto "bigger is better", the most spectacular episode in the history of life preserved in the fossil record has to do, not with dinosaurs, but with the appearance in the Cambrian era [beginning about 450 million years (My) ago] of an astounding variety of complex multicellular animal life. The Cambrian fauna included not(More)
Ubiqitination is an important process in eukaryotic cells involving E3 ubiquitin ligase, which co-ordinates with cell cycle proteins and controls various cell functions. Skp1 (S-phase kinase-associated protein 1) is a core component of the SCF (Skp1-Cullin 1-F-box) E3 ubiquitin ligase complex necessary for protein degradation by the 26S proteasomal pathway.(More)
Magnaporthe oryzae, the causative organism of rice blast, infects cereal crops and grasses at various stages of plant development. A comprehensive understanding of its metabolism and the implications on pathogenesis is necessary for countering this devastating crop disease. We present the role of the CorA magnesium transporters, MoAlr2 and MoMnr2, in(More)
A major conundrum in evolutionary biology, about as old as the discipline itself, has been the question of how major changes in body form can come about. Darwin himself insisted on a strict gradualism in all evolutionary change. Even the radical reorganization of body plans was assumed by Darwin to proceed through many small, graded steps. This view, still(More)
The field of epigenetics has grown explosively in the past two decades or so. As currently defined, epigenetics deals with heritable, metastable and usually reversible changes that do not involve alterations in DNA sequence, but alter the way that information encoded in DNA is utilized. The bulk of current research in epigenetics concerns itself with(More)
Two-component signal transduction (TCST) pathways play crucial roles in many cellular functions such as stress responses, biofilm formation, and sporulation. The histidine phosphotransferase (HPt), which is an intermediate phosphotransfer protein in a two-component system, transfers a phosphate group to a phosphorylatable aspartate residue in the target(More)
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