Johannes Koomen

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In experiments in which guinea pigs were infected concurrently with the virus of lymphocytic choriomeningitis and the parasitic nematode, Trichinella spiralis, proof was obtained that trichinella larvae, after maturation in the muscles, had acquired the virus and were capable of transmitting it to new susceptible hosts. Transmission resulted both when(More)
This review elucidates the state-of-the-art knowledge about pathogen population heterogeneity and describes the genotypic and phenotypic analyses of persister subpopulations and stress-resistant variants. The molecular mechanisms underlying the generation of persister phenotypes and genetic variants are identified. Zooming in on Listeria monocytogenes, a(More)
This case study describes the collaboration between Xerox Research and The Henry Ford Museum to explore ways to enable museum staff and visitors to interact with artifacts and each other in online environments. Building on the premise that stories are an integral part of the museum experience, the team developed prototype technologies, initially for use by(More)