Johannes Koomen

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In experiments in which guinea pigs were infected concurrently with the virus of lymphocytic choriomeningitis and the parasitic nematode, Trichinella spiralis, proof was obtained that trichinella larvae, after maturation in the muscles, had acquired the virus and were capable of transmitting it to new susceptible hosts. Transmission resulted both when(More)
This review elucidates the state-of-the-art knowledge about pathogen population heterogeneity and describes the genotypic and phenotypic analyses of persister subpopulations and stress-resistant variants. The molecular mechanisms underlying the generation of persister phenotypes and genetic variants are identified. Zooming in on Listeria monocytogenes, a(More)
A comparative approach has been employed in many phases of medicine, eg, epidemiology, surgery, nutrition, cancer. It has been used widely in teaching, research, and surveillance, but little attention has been paid to its application in delivery systems. Geographic and financial circumstances often create situations in which it is extremely difficult to(More)