Johannes Gottanka

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PURPOSE To correlate morphologic changes in the retinal vasculature with degenerative changes in the neuronal retina of mice lacking 56 amino acids from the N-terminus of the Norrie disease (ND) gene product. METHODS Posterior eye segments of ND mice of different age groups were investigated by light and electron microscopy (EM) and scanning EM of(More)
PURPOSE We wished to determine whether eyes with primary open-angle glaucoma (POAG) and differing severity of optic nerve damage also have differences in severity of trabecular meshwork changes. METHODS The trabecular meshwork and optic nerve from 26 eyes (14 donors) with the clinical diagnosis of POAG were studied. Severity of disease ranged from(More)
PURPOSE TGF-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open-angle glaucoma (POAG). Studies have shown that TGF-beta2 influences cultured trabecular meshwork (TM) cells, but the effects of this cytokine on intact TM and outflow facility have not been studied. The purpose of this study was to investigate(More)
OBJECTIVES To study the ultrastructure of the trabecular meshwork in human eyes with corticosteroid-induced glaucoma and to determine whether the changes noted also occur in the eyes of patients with primary open-angle glaucoma (POAG) who have been treated with corticosteroids. METHODS The trabecular meshwork from 5 patients in whom corticosteroid-induced(More)
PURPOSE To determine whether differences in the optic nerve occur in eyes with primary versus secondary open-angle glaucoma. METHODS Optic nerves obtained at autopsy from 36 eyes with primary open-angle glaucoma (POAG) and 15 with pseudoexfoliation glaucoma (PEXG) were studied quantitatively and qualitatively. Axon counts, fibrosis, capillary number and(More)
PURPOSE To determine whether the severity of glaucomatous damage in eyes with pseudoexfoliative (PEX) glaucoma is related to the amount of PEX material in the trabecular meshwork. METHODS Trabecular meshwork and optic nerves from 19 eyes (11 donors) with PEX syndrome were studied. Eyes were chosen to represent all stages of severity of disease. Sections(More)
PURPOSE To determine in rhesus monkeys the age-dependence of uveoscleral outflow (Fu) and morphology of the trabecular meshwork (TM) and anterior ciliary muscle (CM). METHODS Intraocular pressure (IOP) was measured by Goldmann applanation tonometry in monkeys under ketamine anesthesia. After anterior chamber cannulation under pentobarbital anesthesia,(More)
PURPOSE To investigate the effects of high intraocular pressure (h-IOP) on TIGR/MYOC expression, extracellular matrix (ECM) deposition, and outflow facility (C) in perfused human anterior segment cultures. METHODS Anterior segments of 31 pairs of normal human eyes from postmortem donors were perfused at constant flow (3 microl/min). After reaching stable(More)
PURPOSE To investigate the morphologic changes in the trabecular meshwork in a case series of eyes with pigment dispersion syndrome and pigmentary glaucoma, and surgical trabeculectomy specimens from eyes with pigmentary glaucoma. MATERIALS AND METHODS Trabecular meshworks from 6 whole eyes from 3 donors and 7 trabeculectomy specimens were studied by(More)
Purpose: To determine whether β-adrenergic blocker (β-blocker) therapy for glaucoma causes changes in the trabecular meshwork due to underperfusion. Methods: Thirty-five eyes from 19 donors with primary open-angle glaucoma (POAG) were divided into three groups: eyes receiving β-blocker therapy along with standard medications, eyes receiving standard(More)