Johannes Franz

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We have investigated the inhibition of Escherichia coli glutamine synthetase (GS) with alpha- and gamma-substituted analogues of phosphinothricin [L-2-amino-4-(hydroxymethylphosphinyl)butanoic acid (PPT)], a naturally occurring inhibitor of GS. These compounds display inhibition of bacterial GS that is competitive vs L-glutamate, with Ki values in the low(More)
Cell-penetrating peptides (CPPs) are short membrane-permeating amino acid sequences that can be used to deliver cargoes, e.g. drugs, into cells. The mechanism for CPP internalization is still subject of ongoing research. An interesting family of CPPs is the sweet arrow peptides - SAP(E) - which are known to adopt a polyproline II helical secondary(More)
Glutamine synthetase (GS) utilizes various substituted glutamic acids as substrates. We have used this information to design herbicidal alpha- and gamma-substituted analogs of phosphinothricin (l-2-amino-4-(hydroxymethylphosphinyl)butanoic acid, PPT), a naturally occurring GS inhibitor and a potent herbicide. The substituted phosphinothricins inhibit(More)
Ovine brain glutamine synthetase (GS) utilizes various substituted glutamic acids as substrates. We have used this information to design alpha- and gamma-substituted analogues of phosphinothricin [L-2-amino-4-(hydroxymethylphosphinyl)butanoic acid], a naturally occurring inhibitor of GS. These compounds display competitive inhibition of GS, and a(More)
Cell-penetrating peptides (CPPs) are promising molecules as drug carriers. However, because their uptake mainly involves endocytic mechanisms, endosomal trapping of the carrier (and drug) remains a high barrier for biomedical applications. The viral fusion mimic GALA, a pH-triggered CPP, takes advantage of the decreasing pH during endosome maturation to(More)
The surface-active ions tetraphenylarsonium (Ph4As(+)) and tetraphenylboron (Ph4B(-)) have a similar structure but opposite charge. At the solution-air interface, the two ions affect the surface tension in an identical manner, yet sum-frequency generation (SFG) spectra reveal an enhanced surface propensity for Ph4As(+) compared with Ph4B(-), in addition to(More)
4/3a 0 £ 4/3a 0 modulations and pseudogap variations changes subtly so that the A(R, E) (insets in Fig. 4) appear very similar between dopings. Thus, the checkerboard electronic state appears for x # 0.08 in the ZTPG regime but continues to exist for p . pSC, the critical doping for superconductivity. We recently introduced a conjecture on underdoped(More)
The low-toxic synthetic growth regulators, N-oxides of pyridine derivatives, activate growth of plants and affect the metabolic processes of plant cells. Uptake of minerals is one of the most important functions of roots. Ion uptake depends on the function of proton pump represented by plasma membrane H+-ATPase. We have been investigated the influence of(More)
Biophysical studies of the interaction of peptides with model membranes provide a simple yet effective approach to understand the transport of peptides and peptide based drug carriers across the cell membrane. Herein, the authors discuss the use of self-assembled monolayers fabricated from the full membrane-spanning thiol (FMST)(More)