Johannes Forster

Marcus Krueger4
Andrea Heinzmann4
Jessica Heinze3
Beena Puthothu3
Karl E. Bergmann2
4Marcus Krueger
4Andrea Heinzmann
3Jessica Heinze
3Beena Puthothu
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The aim of this study was to determine the prevalence of respiratory viruses and to prospectively evaluate the performance of the fast-track diagnostics (FTD) respiratory pathogens multiplex PCR assay shortly after the 2009/10 influenza pandemic. Highly sensitive monoplex real-time PCR assays served as references. Discrepant results were further analyzed by(More)
  • Lia van der Hoek, Klaus Sure, Gabriele Ihorst, Alexander Stang, Krzysztof Pyrc, Maarten F Jebbink +4 others
  • 2005
BACKGROUND The clinical relevance of infections with the novel human coronavirus NL63 (HCoV-NL63) has not been investigated systematically. We therefore determined its association with disease in young children with lower respiratory tract infection (LRTI). METHODS AND FINDINGS Nine hundred forty-nine samples of nasopharyngeal secretions from children(More)
BACKGROUND Interleukin 8 (IL8) belongs to the family of chemokines. It mediates the activation and migration of neutrophils from peripheral blood into tissue and hereby plays a pivotal role in the initiation of inflammation. Thus it is important in inflammatory lung diseases like bronchial asthma or severe infections by Respiratory Syncytial Virus (RSV).(More)
Respiratory syncytial virus (RSV) is the most common viral respiratory pathogen during infancy world wide. It induces innate and adaptive immune response in host cells. The toll like receptor 4 (TLR4)/CD14 complex is particularly important for the initiation of an innate immune response to RSV. Thus we were interested whether an association exists between(More)
BACKGROUND Surfactant proteins (SP) are important for the innate host defence and essential for a physiological lung function. Several linkage and association studies have investigated the genes coding for different surfactant proteins in the context of pulmonary diseases such as chronic obstructive pulmonary disease or respiratory distress syndrome of(More)
Toll like receptors (TLRs) are an essential part of the innate immune response. So far, ten different TLRs were identified in humans. They recognize a wide range of microbial and viral pathogens. Infection by respiratory syncytial virus (RSV) is still a major health problem, about 2% of all children are hospitalised due to RSV bronchiolitis during their(More)
BACKGROUND A novel non-invasive asthma prediction tool from the Leicester Cohort, UK, forecasts asthma at age 8 years based on 10 predictors assessed in early childhood, including current respiratory symptoms, eczema, and parental history of asthma. OBJECTIVE We aimed to externally validate the proposed asthma prediction method in a German birth cohort.(More)
Platelets seem to play a role in the development of ovarian cancer. Platelet count (PLT) is an ubiquitous available parameter. We analyzed retrospectively data of 756 patients with primary adnexal tumors: 584 benign and 172 malignant (148 invasive and 24 borderline) cases. We compared the diagnostic accuracy of CA125, PLT, and a combination of CA125 and(More)
Kaufempfehlungen werden für den Online-Handel in Zukunft zu einem immer entscheidenderen Instrument, um Kunden zu binden. Für kleinere Online-Händler ist die Entwicklung und Pflege komplexer Empfehlungssysteme nicht machbar. Zudem verfügen sie meist über ein vergleichsweise kleines Sortiment und können daher kaum Empfehlungen generieren. In diesem Beitrag(More)