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The verification of thermal models for use in hyperthermia treatment planning is essential. We investigated the heat transfer between a single vessel and the surrounding vascularised tissue, comparing the conventional bioheat transfer theory and the recently developed keff model using analytical and numerical methods. A plastic tube inserted into the tissue(More)
Hyperthermia treatment planning (HTP) is an important tool to improve the quality of hyperthermia treatment. It is a practical way of designing new hyperthermia systems and can be used to optimize the phase and amplitude settings to achieve optimal heating. One of the main challenges to be dealt with however is the uncertainty in the modeling parameters.(More)
The in vivo electric conductivity (σ) values of tissue are essential for accurate electromagnetic simulations and specific absorption rate (SAR) assessment for applications such as thermal dose computations in hyperthermia. Currently used σ-values are mostly based on ex vivo measurements. In this study the conductivity of human muscle, bladder content and(More)
PURPOSE To analyse the therapeutic effect and toxicity of re-irradiation (re-RT) combined with hyperthermia (HT) following resection or clinically complete remission (CR) of persistent locoregional recurrent breast cancer in previously irradiated area. METHODS AND MATERIALS Between 1988 and 2001, 78 patients with high risk recurrent breast cancer(More)
PURPOSE To analyse the treatment results of neo-adjuvant chemoradiation combined with regional hyperthermia in patients with resectable esophageal cancer. PATIENTS AND METHODS Between August 2003 and December 2004, 28 patients entered a phase II study combining chemoradiation over a 4.5-week period with five sessions of regional hyperthermia. Chemotherapy(More)
Accurate treatment planning is necessary for the successful application of hyperthermia in the clinic. The validity of four different bioheat models or combinations of models is evaluated: the conventional bioheat transfer equation, the limited effective conductivity model, a mixed heat sink-effective conductivity model and a discrete vessel model. The heat(More)
Isolated perfused bovine tongues were heated with a 2 x 2 hot water tube interstitial hyperthermia system (tube outer diameter 2.0 mm, spacing 16 mm). Tongue blood flow ranged between 0 and 17 ml min-1/100 g. The temperature distribution was mapped with 5 to 8 single thermocouples (diameter 50 microns). Model predictions using both the conventional bioheat(More)
BACKGROUND The aim of this study is preclinical evaluation of our newly developed regional hyperthermia system providing 3-D SAR control: the AMC-8 phased array consisting of two rings, each with four 70 MHz waveguides. It was designed to achieve higher tumour temperatures and improve the clinical effectiveness of locoregional hyperthermia. METHODS The(More)
In regional hyperthermia, optimization techniques are valuable in order to obtain amplitude/phase settings for the applicators to achieve maximal tumour heating without toxicity to normal tissue. We implemented a temperature-based optimization technique and maximized tumour temperature with constraints on normal tissue temperature to prevent hot spots.(More)
We have developed a thermal model in which blood vessels are described as geometrical objects, 3D curves with associated diameters. Here the behaviour of the model is examined for low resolutions compared with the vessel diameter and for strongly curved vessels. The tests include a single straight vessel and vessels describing the path of a helix embedded(More)