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OBJECTIVE To investigate in patients with essential tremor (ET) treated with thalamic/subthalamic deep brain stimulation (DBS) whether stimulation-induced dysarthria (SID) can be diminished by individualized current-shaping with interleaving stimulation (cs-ILS) while maintaining tremor suppression (TS). METHODS Of 26 patients screened, 10 reported SID(More)
Observing cellular responses to perturbations is central to generating and testing hypotheses in biology. We developed a massively parallel microchemostat array capable of growing and observing 1,152 yeast-GFP strains on the single-cell level with 20 min time resolution. We measured protein abundance and localization changes in 4,085 GFP-tagged strains in(More)
PURPOSE Chronic deep brain stimulation of the nucleus ventralis intermedius is an effective treatment for individuals with medication-resistant essential tremor. However, these individuals report that stimulation has a deleterious effect on their speech. The present study investigates one important factor leading to these effects: the coordination of oral(More)
JEL classification: D63 H23 Q54 Keywords: Climate change Discounting Infinitely lived agents Intergenerational equity Overlapping generations Time preference a b s t r a c t The prevailing literature discusses intergenerational trade-offs in climate change predominantly in terms of the Ramsey equation relying on the infinitely lived agent model. We discuss(More)
This study reports on a production experiment investigating tonal and articulatory means of encoding different focus structures in German. Using an electromagnetic articulograph, we examined the movements of the upper and lower lips (related to sonority expansion) during the production of target words occurring in four different focus conditions. We found(More)
The prevailing literature discusses intergenerational trade-offs predominantly in infinitely-lived agent models despite the finite lifetime of individuals. We discuss these trade-offs in a continuous time OLG framework and relate the results to the infinitely-lived agent setting. We identify three shortcomings of the latter: First, underlying normative(More)
and Klaus Ritzeberger for helpful discussions and comments. Financial support by the DFG is greate-fully acknowledged. I consider an economy, populated by case-based decision makers with one-period memory. Consumption can be transferred between the periods by the means of a risk-less storage technology or a risky asset with iid dividend payments. I analyze(More)