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As guardian of the genome the tumor suppressor p53 controls a crucial point in protection from cellular damage and response to stressors. Activation of p53 can have beneficial (DNA repair) or detrimental (apoptosis) consequences for individual cells. In either case activation of p53 is thought to safeguard the organism at large from the deleterious effects(More)
Hyperactivation of p53 leads to a reduction in tumor formation and an unexpected shortening of life span in two different model systems . The decreased life span occurs with signs of accelerated aging, such as osteoporosis, reduction in body weight, atrophy of organs, decreased stress resistance, and depletion of hematopoietic stem cells. These observations(More)
The p75 neurotrophin receptor (p75(NTR)) belongs to the tumor necrosis factor receptor/nerve growth factor receptor superfamily. In some cells derived from neuronal tissues it causes cell death through a poorly characterized pathway. We developed a neuronal system using conditionally immortalized striatal neurons, in which the expression of p75(NTR) is(More)
Calorie Restriction (CR) is a well established method of extending life span in a variety of organisms. In the fruit fly D. melanogaster, CR is mediated at least in part by activation of dSir2. In mammalian systems, one of the critical targets of Sir2 is the tumor suppressor p53. This deacetylation of p53 by Sir2 leads to inhibition of p53's transcriptional(More)
We present an algorithm based on the self-organizing map (SOM) which models multi-sensory integration as realized by the superior colliculus (SC). Our algorithm differs from other algorithms for multi-sensory integration in that it learns mappings between modalities' coordinate systems, it learns their respective reliabilities for different points in space,(More)
Cardiotrophin-like cytokine:cytokine-like factor-1 (CLC:CLF-1) is a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development. Mice lacking CLC:CLF-1 die soon after birth due to a suckling defect and show reduced numbers of motor neurons. Humans carrying mutations in CLC:CLF-1 develop similar disorders, known as Sohar-Crisponi(More)
Two experiments were designed to determine if pregnant and lactating rats are differentially attracted to their own bedding at various stages of the reproductive cycle and whether they will discriminate between their own nest materials and those of virgins and other lactating animals. We found that from just before birth until the second week postpartum,(More)
A major challenge in translating the positive effects of dietary restriction (DR) for the improvement of human health is the development of therapeutic mimics. One approach to finding DR mimics is based upon identification of the proximal effectors of DR life span extension. Whole genome profiling of DR in Drosophila shows a large number of changes in gene(More)
—Considerable time and effort often go into designing and implementing experimental setups (ES) in robotics. These activities are usually not at the focus of our research and thus go underreported. This results in replication of work and lack of comparability. This paper lays out our view of the theoretical considerations necessary when deciding on the type(More)