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  • Steffi Lehmann, Ramanil K. S. Perera, +13 authors Marina Bacac
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2016 (First Publication: 1 September 2016)
  • PURPOSE CEA TCB (RG7802, RO6958688) is a novel T-cell bispecific antibody, engaging CD3ε upon binding to carcinoembryonic antigen (CEA) on tumor cells. Containing an engineered Fc region, conferringContinue Reading
  • Marina Bacac, Sara Colombetti, +20 authors Pablo Umaña
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2018 (First Publication: 1 October 2018)
  • Purpose: Despite promising clinical activity, T-cell-engaging therapies including T-cell bispecific antibodies (TCB) are associated with severe side effects requiring the use of step-up-dosing (SUD)Continue Reading
  • Christian Klein, Christiane Neumann, +19 authors Pablo Umaña
  • Medicine
  • 2017 (First Publication: 1 July 2017)
  • T cell bispecific antibodies that recruit and engage T cells for tumor cell killing through binding to the T cell receptor (TCR) upon binding to a tumor antigen (TA) and subsequent crosslinking haveContinue Reading