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STAT-3 and ERK 1/2 phosphorylation are critical for T-cell alloactivation and graft-versus-host disease.
Graft-versus-host disease (GVHD) is a serious complication of allogeneic bone marrow transplantation, and donor T cells are indispensable for GVHD. Current therapies have limited efficacy,… Expand
Ceacam1 Separates Graft-versus-Host-Disease from Graft-versus-Tumor Activity after Experimental Allogeneic Bone Marrow Transplantation
- Sydney X. Lu, Lucy W. Kappel, +22 authors M. V. D. van den Brink
- Biology, Medicine
- PloS one
- 6 July 2011
Background Allogeneic bone marrow transplantation (allo-BMT) is a potentially curative therapy for a variety of hematologic diseases, but benefits, including graft-versus-tumor (GVT) activity are… Expand
Ceacam1 Regulates Experimental Graft-Versus-Host-Disease
CEACAM-1 Is Involved in Graft-Versus-Host-Disease in Murine Allogeneic Bone Marrow Transplantation Models.
Carcinoembryonic antigen associated cell adhesion molecule 1 (CEACAM-1) belongs to a family of carcinoembryonic antigen-associated glycoproteins. It is expressed on leukocytes, endothelium, and… Expand
Aplicación de un algoritmo diagnóstico de laboratorio para la detección de hemoglobinopatías
Hemoglobinopathies are qualitative or quantitative genetic disorders that affect the globin chains, whose consequence may be a structural modification (structural hemoglobinopathies) or a decrease in… Expand
Discovery and Validation of STAT-3 and ERK1/2 Phosphorylation as Critical for the Function of Alloactivated T Cells in Acute Graft-Versus-Host-Disease Via a Novel Technique for Drug Discovery.
Graft-versus-host-disease (GVHD) is a serious complication of allogeneic bone marrow transplantation (allo-BMT). The physiology of GVHD is dominated by alloactivated donor T cells, yet current… Expand
P-Selectin Regulates Leukocyte Trafficking And Experimental Graft-Versus-Host-Disease After Allogeneic Bone Marrow Transplantation