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Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors
Cocaine-induced plasticity of glutamatergic synaptic transmission in the ventral tegmental area (VTA) plays an important role in brain adaptations that promote addictive behaviors. However, theExpand
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Prolonged Withdrawal from Repeated Noncontingent Cocaine Exposure Increases NMDA Receptor Expression and ERK Activity in the Nucleus Accumbens
Cocaine-induced changes in glutamatergic synaptic transmission in the ventral tegmental area (VTA) and the nucleus accumbens (NAc) play a key role in cocaine behavioral effects. Activation ofExpand
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Src‐protein tyrosine kinases are required for cocaine‐induced increase in the expression and function of the NMDA receptor in the ventral tegmental area
Cocaine‐induced long‐term potentiation of glutamatergic synapses in the ventral tegmental area (VTA) has been proposed as a key process that contributes to the development of addictive behaviors. InExpand
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Inhibition of NR2B phosphorylation restores alterations in NMDA receptor expression and improves functional recovery following traumatic brain injury in mice.
Traumatic brain injury (TBI) triggers a massive glutamate efflux, hyperactivation of N-methyl-D-aspartate receptors (NMDARs) and neuronal cell death. Previously it was demonstrated that, 15 minExpand
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D‐cycloserine improves functional recovery and reinstates long‐term potentiation (LTP) in a mouse model of closed head injury
Traumatic brain injury triggers a massive glutamate efflux, activation of NMDA receptor channels, and cell death. Recently, we reported that NMDA receptors in mice are down‐regulated from hours toExpand
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NR2A/B-containing NMDA receptors mediate cocaine-induced synaptic plasticity in the VTA and cocaine psychomotor sensitization
Cocaine-induced modifications of glutamatergic synaptic transmission in the mesolimbic system play a key role in adaptations that promote addictive behaviors. In particular, the activation ofExpand
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Metadoxine In ADHD and fragile X syndrome: a novel mechanism of action
BACKGROUND • Metadoxine is an ion-pair salt of pyridoxine (vitamin B6 and a precursor of pyridoxal phosphate) and 2-pyrrolidone-5-carboxylate (PCA, also known as L-PGA) that has been used for moreExpand
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Zusammenhang zwischen Ausmaß der Verlagerungsstrecke und einem postoperativ auftretenden Rezidiv bei kieferchirurgischer Korrektur von Klasse II Dysgnathien
In dieser retrospektiven Studie wurden von 30 konsekutiven Klasse II Patienten, die eine operative Unterkiefervorverlagerung nach Obwegeser Dal Pont zur Korrektur der Dysgnathie erfahren haben, dieExpand