Johanna Scheibe

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The astrocytic response to ischemic brain injury is characterized by specific alterations of glial cell morphology and function. Various studies described both beneficial and detrimental aspects of activated astrocytes, suggesting the existence of different subtypes. We investigated this issue using a novel object-based approach to study characteristics of(More)
INTRODUCTION Cerebral small vessel disease (cSVD) is one of the most prevalent neurological disorders. The progressive remodeling of brain microvessels due to arterial hypertension or other vascular risk factors causes subtle, but constant cognitive decline through to manifest dementia and substantially increases the risk for stroke. Preliminary evidence(More)
Arterial hypertension is not only the leading risk factor for stroke, but also attributes to impaired recovery and poor outcome. The latter could be explained by hypertensive vascular remodeling that aggravates perfusion deficits and blood-brain barrier disruption. However, besides vascular changes, one could hypothesize that activation of the immune system(More)
Fetal human neural precursor cells (NPCs) are unique with respect to their capacity to proliferate and to preserve their potential to differentiate into neurons and glia. Human mesencephalic neural precursor cells (hmNPCs) provide a source for dopaminergic neurons. Preclinical and clinical research will benefit from reliable in vivo tracking of transplanted(More)
Ischemic stroke swiftly induces a wide spectrum of pathophysiological sequelae, particularly in the aged brain. The translational failure of experimental therapies, might partially be related to monotherapeutic approaches, not address potential counter-mechanisms sufficiently or within the best time window. For example, therapeutic effects relying on(More)
37 patients with muscle disease (23 myopathies and 14 neurogenic muscle diseases) were studied by spiroergometric investigations. The multivariate analysis of variance (MA-NOVA) and linear discriminant analyses indicated the diagnostic effectiveness of the maximal work capacity/maximal cardiac frequency ratio. The sensitivity was found to be 0.81 and the(More)
Methods of instrumental diagnosis, which are used to provide evidence for the absence of complications associated with inflammatory processes of the central nervous system and which often give unsatisfactory results in addition to being accompanied by major risks, are compared with long-time scintigraphic reexaminactions which involve no danger to the(More)
With reference to the special position of neurotoxoplasmosis in regard of the detection of postnatal infection with Toxoplasma gondii the authors present 18 cases of this illness. The main factor responsible for the diagnostic uncertainty proves to be the blood-brain-liquor barrier which is responsible both for the behaviour of the parasite in the CNS and(More)
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